Translational Neuroscience in Autism: From Neuropathology to Transcranial Magnetic Stimulation Therapies

Manuel F. Casanova, Estate M. Sokhadze, Emily L. Casanova, Ioan Opris, Caio Abujadi, Marco Antonio Marcolin, Xiaoli Li

Research output: Contribution to journalReview articlepeer-review

Abstract

The presence of heterotopias, increased regional density of neurons at the gray-white matter junction, and focal cortical dysplasias all suggest an abnormality of neuronal migration in autism spectrum disorder (ASD). The abnormality is borne from a dissonance in timing between radial and tangentially migrating neuroblasts to the developing cortical plate. The uncoupling of excitatory and inhibitory cortical cells disturbs the coordinated interactions of neurons within local networks, thus providing abnormal patterns of brainwave activity in the gamma bandwidth. In ASD, gamma oscillation abnormalities and autonomic markers offer measures of therapeutic progress and help in the identification of subgroups.

Original languageEnglish (US)
Pages (from-to)229-248
Number of pages20
JournalPsychiatric Clinics of North America
Volume43
Issue number2
DOIs
StatePublished - Jun 2020
Externally publishedYes

Keywords

  • Autism spectrum disorder
  • Executive function
  • Gamma oscillations
  • Minicolumns
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health

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