TY - JOUR
T1 - Translational Neuroendocrinology of Human Skin
T2 - Concepts and Perspectives
AU - Ramot, Yuval
AU - Böhm, Markus
AU - Paus, Ralf
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/1
Y1 - 2021/1
N2 - Human skin responds to numerous neurohormones, neuropeptides, and neurotransmitters that reach it via the vasculature or skin nerves, and/or are generated intracutaneously, thus acting in a para- and autocrine manner. This review focuses on how neurohormones impact on human skin physiology and pathology. We highlight basic concepts, major open questions, and translational research perspectives in cutaneous neuroendocrinology and argue that greater emphasis on neuroendocrine human skin research will foster the development of novel dermatological therapies. Furthermore, human skin and its appendages can be used as highly accessible and clinically relevant model systems for probing nonclassical, ancestral neurohormone functions. This calls for close interdisciplinary collaboration between dermatologists, skin biologists, neuroendocrinologists, and neuropharmacologists.
AB - Human skin responds to numerous neurohormones, neuropeptides, and neurotransmitters that reach it via the vasculature or skin nerves, and/or are generated intracutaneously, thus acting in a para- and autocrine manner. This review focuses on how neurohormones impact on human skin physiology and pathology. We highlight basic concepts, major open questions, and translational research perspectives in cutaneous neuroendocrinology and argue that greater emphasis on neuroendocrine human skin research will foster the development of novel dermatological therapies. Furthermore, human skin and its appendages can be used as highly accessible and clinically relevant model systems for probing nonclassical, ancestral neurohormone functions. This calls for close interdisciplinary collaboration between dermatologists, skin biologists, neuroendocrinologists, and neuropharmacologists.
KW - CNS
KW - HPA
KW - HPT
KW - dermatology
KW - endocrinology
UR - http://www.scopus.com/inward/record.url?scp=85091608574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85091608574&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2020.09.002
DO - 10.1016/j.molmed.2020.09.002
M3 - Review article
C2 - 32981840
AN - SCOPUS:85091608574
VL - 27
SP - 60
EP - 74
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 1
ER -