Translational aspects of sphingolipid metabolism

Youssef H. Zeidan, Yusuf A. Hannun

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations

Abstract

Sphingolipids, a major class of lipids in cell membranes, play diverse roles in biological processes. As bioactive and structural molecules, they have signaling activities and biophysical properties that are essential for regulating various cellular, tissue and systemic functions. Moreover, sphingolipids are receiving increasing attention as contributors to the pathogenesis of several human disorders, including, cancer, inflammation and neurological, immune and metabolic disorders. Small-molecule inhibitors and monoclonal antibodies that target sphingolipid metabolism recently enabled giant strides toward treatment of malignant and autoimmune disorders. Here, we review the emerging roles of sphingolipids in disease pathogenesis and the attendant possibilities for sphingolipid-based therapeutics.

Original languageEnglish (US)
Pages (from-to)327-336
Number of pages10
JournalTrends in Molecular Medicine
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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