Over a 5-year period, 21 patients were diagnosed with transitional cell carcinoma (TCC) of the prostate. Tumor was primary to the prostate in 3 patients, but was associated with TCC of the bladder in the remaining 18. Ten patients developed TCC of the prostate following intravesical therapy for TCC of the bladder. Patients were staged according to local tumor extent, with 2 having disease confined to the prostatic urothelium, 7 showing invasion into ducts and 12 with stromal involvement. None of the 21 patients had metastatic disease at diagnosis. A total of 14 patients underwent radical cystoprostatectomy as primary therapy, while the remaining 7 were managed without radical surgery, receiving intravesical therapy, transurethral resection, systemic chemotherapy, and radiotherapy, singly or in combination. Minimum follow-up was 22 months, with an average of 35 months. Twelve patients (57%) are alive with no evidence of disease, 3 (14%) are alive with tumor and 6 (29%) have died - 5 (24%) of progressive tumor.
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