Transient receptor potential channels and dermatological disorders

Rodrigo Valdes-Rodriguez, Shivani B. Kaushik, Gil Yosipovitch

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Transient receptor potential (TRP) cation channels are an emerging field of research in dermatology. Beyond their classical role in skin sensory perception, TRPs are involved in various cutaneous functions that include keratinocyte differentiation, apoptosis and melanocyte pigmentation. In addition, they have a role as pharmacological targets in many inflammatory skin diseases including psoriasis, chronic itch, hair disorders and skin cancers. Moreover, mutations in TRPs have recently been related to rare skin conditions such as Olmsted syndrome. This review will cover the role of TRPs in dermatologic conditions with special emphasis on itch and skin inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)335-343
Number of pages9
JournalCurrent Topics in Medicinal Chemistry
Volume13
Issue number3
DOIs
StatePublished - Apr 30 2013
Externally publishedYes

Keywords

  • Hair growth
  • Itch
  • Skin barrier
  • Skin cancers
  • TRPA
  • TRPC
  • TRPM
  • TRPML
  • TRPV

ASJC Scopus subject areas

  • Drug Discovery

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