TY - JOUR
T1 - Transient Ischemic Attack Before Nonlacunar Ischemic Stroke in the Elderly
AU - Della Morte, David
AU - Abete, Pasquale
AU - Gallucci, Ferdinando
AU - Scaglione, Anna
AU - D'Ambrosio, Daniele
AU - Gargiulo, Gaetano
AU - De Rosa, Giovanna
AU - Dave, Kunjan R.
AU - Lin, Hung Wen
AU - Cacciatore, Francesco
AU - Mazzella, Francesca
AU - Uomo, Generoso
AU - Rundek, Tanja
AU - Perez-Pinzon, Miguel A.
AU - Rengo, Franco
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/9
Y1 - 2008/9
N2 - Background: Several studies suggest transient ischemic attack (TIA) may be neuroprotective against ischemic stroke analogous to preinfarction angina's protection against acute myocardial infarction. However, this protective ischemic preconditioning-like effect may not be present in all ages, especially among the elderly. The purpose of this study was to determine the neuroprotective effect of TIAs (clinical equivalent of cerebral ischemic preconditioning) to neurologic damage after cerebral ischemic injury in patients over 65 years of age. Methods: We reviewed the medical charts of patients with ischemic stroke for presence of TIAs within 72 hours before stroke onset. Stroke severity was evaluated by the National Institutes of Health Stroke Scale and disability by a modified Rankin scale. Results: We evaluated 203 patients (≥65 years) with diagnosis of acute ischemic stroke and categorized them according to the presence (n = 42, 21%) or absence (n = 161, 79%) of TIAs within 72 hours of stroke onset. Patients were monitored until discharged from the hospital (length of hospital stay 14.5 ± 4.8 days). No significant differences in the National Institutes of Health Stroke Scale and modified Rankin scale scores were observed between those patients with TIAs and those without TIAs present before stroke onset at admission or discharge. Conclusion: These results suggest that the neuroprotective mechanism of cerebral ischemic preconditioning may not be present or functional in the elderly.
AB - Background: Several studies suggest transient ischemic attack (TIA) may be neuroprotective against ischemic stroke analogous to preinfarction angina's protection against acute myocardial infarction. However, this protective ischemic preconditioning-like effect may not be present in all ages, especially among the elderly. The purpose of this study was to determine the neuroprotective effect of TIAs (clinical equivalent of cerebral ischemic preconditioning) to neurologic damage after cerebral ischemic injury in patients over 65 years of age. Methods: We reviewed the medical charts of patients with ischemic stroke for presence of TIAs within 72 hours before stroke onset. Stroke severity was evaluated by the National Institutes of Health Stroke Scale and disability by a modified Rankin scale. Results: We evaluated 203 patients (≥65 years) with diagnosis of acute ischemic stroke and categorized them according to the presence (n = 42, 21%) or absence (n = 161, 79%) of TIAs within 72 hours of stroke onset. Patients were monitored until discharged from the hospital (length of hospital stay 14.5 ± 4.8 days). No significant differences in the National Institutes of Health Stroke Scale and modified Rankin scale scores were observed between those patients with TIAs and those without TIAs present before stroke onset at admission or discharge. Conclusion: These results suggest that the neuroprotective mechanism of cerebral ischemic preconditioning may not be present or functional in the elderly.
KW - Cerebral ischemic preconditioning
KW - elderly
KW - stroke
KW - transient ischemic attack
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U2 - 10.1016/j.jstrokecerebrovasdis.2008.03.004
DO - 10.1016/j.jstrokecerebrovasdis.2008.03.004
M3 - Article
C2 - 18755403
AN - SCOPUS:49949107920
VL - 17
SP - 257
EP - 262
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
SN - 1052-3057
IS - 5
ER -