Transient glucose hypermetabolism after acute subdural hematoma in the rat

Y. Kuroda, F. M. Inglis, J. D. Miller, J. McCulloch, D. I. Graham, Ross Bullock

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Ischemic brain damage occurs in most patients with acute subdural hematoma, yet many aspects of the distribution and extent of this damage remain unexplained. Previous studies in rat model, which produces a region of infarction under the hematoma, have implicated an 'excitotoxic' mechanism, suggesting that high concentrations of excitatory amino acids may exacerbate ischemic damage. A study is described in which local glucose utilization is measured 2 or 4 hours after induction of acute subdural hematoma in the rat. These changes are compared to those produced by introducing the same volume of inert silicone gel into the subdural space. Massive increases (up to 142%) in glucose utilization occurred throughout both hippocampi and in a variable zone around the ischemic core, but these had normalized by 4 hours after blood injection. Hippocampal hypermetabolism was not seen after introduction of the silicone mass, suggesting that diffusible substances from the clotted blood may be responsible for these changes. This transient hypermetabolism accords with an excitotoxic process, which may amplify brain damage after acute subdural hematoma.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalJournal of Neurosurgery
Volume76
Issue number3
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Hematoma, Subdural, Acute
Glucose
Subdural Space
Silicone Gels
Excitatory Amino Acids
Brain
Silicones
Hematoma
Infarction
Hippocampus
Injections

Keywords

  • glucose utilization
  • hippocampus
  • hypermetabolism
  • ischemia
  • rat
  • subdural hematoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Kuroda, Y., Inglis, F. M., Miller, J. D., McCulloch, J., Graham, D. I., & Bullock, R. (1992). Transient glucose hypermetabolism after acute subdural hematoma in the rat. Journal of Neurosurgery, 76(3), 471-477.

Transient glucose hypermetabolism after acute subdural hematoma in the rat. / Kuroda, Y.; Inglis, F. M.; Miller, J. D.; McCulloch, J.; Graham, D. I.; Bullock, Ross.

In: Journal of Neurosurgery, Vol. 76, No. 3, 01.01.1992, p. 471-477.

Research output: Contribution to journalArticle

Kuroda, Y, Inglis, FM, Miller, JD, McCulloch, J, Graham, DI & Bullock, R 1992, 'Transient glucose hypermetabolism after acute subdural hematoma in the rat', Journal of Neurosurgery, vol. 76, no. 3, pp. 471-477.
Kuroda Y, Inglis FM, Miller JD, McCulloch J, Graham DI, Bullock R. Transient glucose hypermetabolism after acute subdural hematoma in the rat. Journal of Neurosurgery. 1992 Jan 1;76(3):471-477.
Kuroda, Y. ; Inglis, F. M. ; Miller, J. D. ; McCulloch, J. ; Graham, D. I. ; Bullock, Ross. / Transient glucose hypermetabolism after acute subdural hematoma in the rat. In: Journal of Neurosurgery. 1992 ; Vol. 76, No. 3. pp. 471-477.
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