Transient effect of suction on the retinal neurovasculature in myopic patients after small-incision lenticule extraction

Jiayan Liu, Rahul Singh Tonk, Amy Michelle Huang, Elaine Han, Carol L. Karp, Minzhi Zeng, Huyong Zou, Yu Zheng, Wei Luo, Xiangyin Sha, Zhiping Liu

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To characterize retinal neurovasculature changes after small-incision lenticule extraction (SMILE) in myopic patients. SETTING: Ophthalmic Center, the Second Affiliated Hospital of Guangzhou Medical University, China. DESIGN: Prospective interventional study. METHODS: The corrected distance visual acuity/uncorrected distance visual acuity, corrected intraocular pressure (CIOP), and corneal tomography were evaluated at baseline (PRE), postoperative day (POD) 1, and POD 7. Ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thicknesses were measured. The vessel area densities (VADs, %), vessel skeleton densities (VSDs, %), vessel diameter index (VDI), and fractal dimensions (Dbox) of the superficial vascular plexus (SVP) and deep vascular plexus (DVP) were measured in a circular area (ϕ 2.5 mm) centered on the fovea. RESULTS: A total of 38 myopic patients were recruited. The GCIPL thickness was increased after SMILE at POD 1 and POD 7 (P < .01) but no significant changes in the pRNFL thickness. The VAD, VSD, and Dbox of the SVP were decreased at POD 1 (P < .01), but not at POD 7. The VDI in small vessels of the SVP and DVP was decreased at POD 1 (P < .05) and increased at POD 7 (P < .05). Changes in CIOP were positively correlated with changes in the GCIPL thickness. Changes in CIOP were negatively correlated with changes in the VAD of small vessels and the Dbox of total vessels in the DVP. Changes in CIOP were negatively correlated with the VSD and VDI of small vessels in the DVP and changes in the VDI of big vessels in the SVP. CONCLUSIONS: The transient fluctuations in the retinal neurovasculature after SMILE may represent a characteristic homeostasis pattern in patients after refractive surgery.

Original languageEnglish (US)
Pages (from-to)250-259
Number of pages10
JournalJournal of cataract and refractive surgery
Volume46
Issue number2
DOIs
StatePublished - Feb 1 2020

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology
  • Sensory Systems

Fingerprint Dive into the research topics of 'Transient effect of suction on the retinal neurovasculature in myopic patients after small-incision lenticule extraction'. Together they form a unique fingerprint.

Cite this