Transgenic Mosquitoes – Fact or Fiction?

André B.B. Wilke, John C. Beier, Giovanni Benelli

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Technologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget species is lacking; no reliable ecological evidence on the potential interactions among GMMs, target populations, and other mosquito species populations exists; and no GMM technology has yet been approved by the WHO Vector Control Advisory Group. Our opinion is that, although GMMs may be considered a promising control tool, more studies are needed to assess their true effectiveness, risks, and benefits. Overall, several lines of evidence must be provided before GMM-based control strategies can be used under the integrated vector management framework.

Original languageEnglish (US)
Pages (from-to)456-465
Number of pages10
JournalTrends in Parasitology
Issue number6
StatePublished - Jun 2018


  • genetically modified mosquitoes
  • integrated vector management
  • mosquito vectors
  • vector-borne diseases

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases


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