Transgenic Mosquitoes – Fact or Fiction?

André B.B. Wilke, John C Beier, Giovanni Benelli

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Technologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget species is lacking; no reliable ecological evidence on the potential interactions among GMMs, target populations, and other mosquito species populations exists; and no GMM technology has yet been approved by the WHO Vector Control Advisory Group. Our opinion is that, although GMMs may be considered a promising control tool, more studies are needed to assess their true effectiveness, risks, and benefits. Overall, several lines of evidence must be provided before GMM-based control strategies can be used under the integrated vector management framework.

Original languageEnglish (US)
JournalTrends in Parasitology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Culicidae
Mosquito Control
Technology
Health Services Needs and Demand
Control Groups
Population

Keywords

  • genetically modified mosquitoes
  • integrated vector management
  • mosquito vectors
  • vector-borne diseases

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Transgenic Mosquitoes – Fact or Fiction? / Wilke, André B.B.; Beier, John C; Benelli, Giovanni.

In: Trends in Parasitology, 01.01.2018.

Research output: Contribution to journalArticle

Wilke, André B.B. ; Beier, John C ; Benelli, Giovanni. / Transgenic Mosquitoes – Fact or Fiction?. In: Trends in Parasitology. 2018.
@article{dd9fc7174bad41299ce1f4062d70d9e5,
title = "Transgenic Mosquitoes – Fact or Fiction?",
abstract = "Technologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget species is lacking; no reliable ecological evidence on the potential interactions among GMMs, target populations, and other mosquito species populations exists; and no GMM technology has yet been approved by the WHO Vector Control Advisory Group. Our opinion is that, although GMMs may be considered a promising control tool, more studies are needed to assess their true effectiveness, risks, and benefits. Overall, several lines of evidence must be provided before GMM-based control strategies can be used under the integrated vector management framework.",
keywords = "genetically modified mosquitoes, integrated vector management, mosquito vectors, vector-borne diseases",
author = "Wilke, {Andr{\'e} B.B.} and Beier, {John C} and Giovanni Benelli",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.pt.2018.02.003",
language = "English (US)",
journal = "Trends in Parasitology",
issn = "1471-4922",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Transgenic Mosquitoes – Fact or Fiction?

AU - Wilke, André B.B.

AU - Beier, John C

AU - Benelli, Giovanni

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Technologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget species is lacking; no reliable ecological evidence on the potential interactions among GMMs, target populations, and other mosquito species populations exists; and no GMM technology has yet been approved by the WHO Vector Control Advisory Group. Our opinion is that, although GMMs may be considered a promising control tool, more studies are needed to assess their true effectiveness, risks, and benefits. Overall, several lines of evidence must be provided before GMM-based control strategies can be used under the integrated vector management framework.

AB - Technologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget species is lacking; no reliable ecological evidence on the potential interactions among GMMs, target populations, and other mosquito species populations exists; and no GMM technology has yet been approved by the WHO Vector Control Advisory Group. Our opinion is that, although GMMs may be considered a promising control tool, more studies are needed to assess their true effectiveness, risks, and benefits. Overall, several lines of evidence must be provided before GMM-based control strategies can be used under the integrated vector management framework.

KW - genetically modified mosquitoes

KW - integrated vector management

KW - mosquito vectors

KW - vector-borne diseases

UR - http://www.scopus.com/inward/record.url?scp=85042905789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042905789&partnerID=8YFLogxK

U2 - 10.1016/j.pt.2018.02.003

DO - 10.1016/j.pt.2018.02.003

M3 - Article

C2 - 29526402

AN - SCOPUS:85042905789

JO - Trends in Parasitology

JF - Trends in Parasitology

SN - 1471-4922

ER -