TY - JOUR
T1 - Transgenic Mosquitoes – Fact or Fiction?
AU - Wilke, André B.B.
AU - Beier, John C.
AU - Benelli, Giovanni
N1 - Funding Information:
This research was supported by CDC ( https://www.cdc.gov/ ) Grant 1U01CK000510-01 : Southeastern Regional Center of Excellence in Vector-Borne Diseases: The Gateway Program. CDC had no role in the design of the study, the collection, analysis, and interpretation of data, or in writing the manuscript.
PY - 2018/6
Y1 - 2018/6
N2 - Technologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget species is lacking; no reliable ecological evidence on the potential interactions among GMMs, target populations, and other mosquito species populations exists; and no GMM technology has yet been approved by the WHO Vector Control Advisory Group. Our opinion is that, although GMMs may be considered a promising control tool, more studies are needed to assess their true effectiveness, risks, and benefits. Overall, several lines of evidence must be provided before GMM-based control strategies can be used under the integrated vector management framework.
AB - Technologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget species is lacking; no reliable ecological evidence on the potential interactions among GMMs, target populations, and other mosquito species populations exists; and no GMM technology has yet been approved by the WHO Vector Control Advisory Group. Our opinion is that, although GMMs may be considered a promising control tool, more studies are needed to assess their true effectiveness, risks, and benefits. Overall, several lines of evidence must be provided before GMM-based control strategies can be used under the integrated vector management framework.
KW - genetically modified mosquitoes
KW - integrated vector management
KW - mosquito vectors
KW - vector-borne diseases
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U2 - 10.1016/j.pt.2018.02.003
DO - 10.1016/j.pt.2018.02.003
M3 - Review article
C2 - 29526402
AN - SCOPUS:85042905789
VL - 34
SP - 456
EP - 465
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 6
ER -