Abstract
The current research improves an original procedure of in-vitro, strain-stimulated skin expansion, which has been shown to be a potential treatment for severe burn victims [1]. This regenerative medicine procedure involves grafting partial thickness skin from the patient, expanding it in-vitro over several days with a strain imparting device in a tissue culture condition, and transplanting it back to the patient thereby doubling the treatment efficacy of a single graft without the undesired mesh scarring associated with the current comparable treatment. This research examines the in-vitro, biological procedure with uncontrolled variability and seeks methods to create a repeatable, controlled manufacturing process with defined quality control parameters and predictable input-output relationships. To this end, the attachment of skin to a strain-inducing bioreactor has been improved, and the process of skin expansion is currently being studied to identify quality control parameters. In overview, this research develops a method for transforming uncontrolled biological procedures into reproducible, controlled manufacturing processes.
| Original language | English |
|---|---|
| Title of host publication | IIE Annual Conference and Expo 2013 |
| Publisher | Institute of Industrial Engineers |
| Pages | 2305-2311 |
| Number of pages | 7 |
| State | Published - Jan 1 2013 |
| Externally published | Yes |
| Event | IIE Annual Conference and Expo 2013 - San Juan, Puerto Rico Duration: May 18 2013 → May 22 2013 |
Other
| Other | IIE Annual Conference and Expo 2013 |
|---|---|
| Country | Puerto Rico |
| City | San Juan |
| Period | 5/18/13 → 5/22/13 |
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Keywords
- Bio-manufacturing
- Design of experiments
- Regenerative medicine
- Tissue engineering
ASJC Scopus subject areas
- Industrial and Manufacturing Engineering
Cite this
Transforming regenerative medicine procedures into manufacturing processes. / Prim, Peter; Jackson, Steven; Cohen, Paul; Wysk, Richard; Lee, Yuan Shin; Kim, James; Kang, Hyun Wook; Jackson, John D.; Lee, Sang Jin; Yoo, James J.; Atala, Anthony.
IIE Annual Conference and Expo 2013. Institute of Industrial Engineers, 2013. p. 2305-2311.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Transforming regenerative medicine procedures into manufacturing processes
AU - Prim, Peter
AU - Jackson, Steven
AU - Cohen, Paul
AU - Wysk, Richard
AU - Lee, Yuan Shin
AU - Kim, James
AU - Kang, Hyun Wook
AU - Jackson, John D.
AU - Lee, Sang Jin
AU - Yoo, James J.
AU - Atala, Anthony
PY - 2013/1/1
Y1 - 2013/1/1
N2 - The current research improves an original procedure of in-vitro, strain-stimulated skin expansion, which has been shown to be a potential treatment for severe burn victims [1]. This regenerative medicine procedure involves grafting partial thickness skin from the patient, expanding it in-vitro over several days with a strain imparting device in a tissue culture condition, and transplanting it back to the patient thereby doubling the treatment efficacy of a single graft without the undesired mesh scarring associated with the current comparable treatment. This research examines the in-vitro, biological procedure with uncontrolled variability and seeks methods to create a repeatable, controlled manufacturing process with defined quality control parameters and predictable input-output relationships. To this end, the attachment of skin to a strain-inducing bioreactor has been improved, and the process of skin expansion is currently being studied to identify quality control parameters. In overview, this research develops a method for transforming uncontrolled biological procedures into reproducible, controlled manufacturing processes.
AB - The current research improves an original procedure of in-vitro, strain-stimulated skin expansion, which has been shown to be a potential treatment for severe burn victims [1]. This regenerative medicine procedure involves grafting partial thickness skin from the patient, expanding it in-vitro over several days with a strain imparting device in a tissue culture condition, and transplanting it back to the patient thereby doubling the treatment efficacy of a single graft without the undesired mesh scarring associated with the current comparable treatment. This research examines the in-vitro, biological procedure with uncontrolled variability and seeks methods to create a repeatable, controlled manufacturing process with defined quality control parameters and predictable input-output relationships. To this end, the attachment of skin to a strain-inducing bioreactor has been improved, and the process of skin expansion is currently being studied to identify quality control parameters. In overview, this research develops a method for transforming uncontrolled biological procedures into reproducible, controlled manufacturing processes.
KW - Bio-manufacturing
KW - Design of experiments
KW - Regenerative medicine
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84900338939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900338939&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84900338939
SP - 2305
EP - 2311
BT - IIE Annual Conference and Expo 2013
PB - Institute of Industrial Engineers
ER -