Abstract
The current research improves an original procedure of in-vitro, strain-stimulated skin expansion, which has been shown to be a potential treatment for severe burn victims [1]. This regenerative medicine procedure involves grafting partial thickness skin from the patient, expanding it in-vitro over several days with a strain imparting device in a tissue culture condition, and transplanting it back to the patient thereby doubling the treatment efficacy of a single graft without the undesired mesh scarring associated with the current comparable treatment. This research examines the in-vitro, biological procedure with uncontrolled variability and seeks methods to create a repeatable, controlled manufacturing process with defined quality control parameters and predictable input-output relationships. To this end, the attachment of skin to a strain-inducing bioreactor has been improved, and the process of skin expansion is currently being studied to identify quality control parameters. In overview, this research develops a method for transforming uncontrolled biological procedures into reproducible, controlled manufacturing processes.
Original language | English |
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Title of host publication | IIE Annual Conference and Expo 2013 |
Publisher | Institute of Industrial Engineers |
Pages | 2305-2311 |
Number of pages | 7 |
State | Published - Jan 1 2013 |
Externally published | Yes |
Event | IIE Annual Conference and Expo 2013 - San Juan, Puerto Rico Duration: May 18 2013 → May 22 2013 |
Other
Other | IIE Annual Conference and Expo 2013 |
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Country | Puerto Rico |
City | San Juan |
Period | 5/18/13 → 5/22/13 |
Keywords
- Bio-manufacturing
- Design of experiments
- Regenerative medicine
- Tissue engineering
ASJC Scopus subject areas
- Industrial and Manufacturing Engineering