Transforming regenerative medicine procedures into manufacturing processes

Peter Prim, Steven Jackson, Paul Cohen, Richard Wysk, Yuan Shin Lee, James Kim, Hyun Wook Kang, John D. Jackson, Sang Jin Lee, James J. Yoo, Anthony Atala

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The current research improves an original procedure of in-vitro, strain-stimulated skin expansion, which has been shown to be a potential treatment for severe burn victims [1]. This regenerative medicine procedure involves grafting partial thickness skin from the patient, expanding it in-vitro over several days with a strain imparting device in a tissue culture condition, and transplanting it back to the patient thereby doubling the treatment efficacy of a single graft without the undesired mesh scarring associated with the current comparable treatment. This research examines the in-vitro, biological procedure with uncontrolled variability and seeks methods to create a repeatable, controlled manufacturing process with defined quality control parameters and predictable input-output relationships. To this end, the attachment of skin to a strain-inducing bioreactor has been improved, and the process of skin expansion is currently being studied to identify quality control parameters. In overview, this research develops a method for transforming uncontrolled biological procedures into reproducible, controlled manufacturing processes.

Original languageEnglish
Title of host publicationIIE Annual Conference and Expo 2013
PublisherInstitute of Industrial Engineers
Number of pages7
StatePublished - Jan 1 2013
Externally publishedYes
EventIIE Annual Conference and Expo 2013 - San Juan, Puerto Rico
Duration: May 18 2013May 22 2013


OtherIIE Annual Conference and Expo 2013
Country/TerritoryPuerto Rico
CitySan Juan


  • Bio-manufacturing
  • Design of experiments
  • Regenerative medicine
  • Tissue engineering

ASJC Scopus subject areas

  • Industrial and Manufacturing Engineering


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