Transforming growth factor beta: Does it direct otic capsule formation?

Dorothy A. Frenz, Thomas R. Van de Water, Vera Galinovíc-Schwartz

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Interactions between the epithelium of the otocyst and surrounding periotic mesenchyme direct the formation of the capsule of the mammalian inner ear. In the present study, we have characterized the temporal-spatial distribution of transforming growth factor beta 1 (TGF-β1) in the epithelial and mesenchymal tissues that compose the inner ear between 10 and 14 days of embryonic development. In addition, using high-density cultures of periotic mesenchyme to model otic capsule formation, we have demonstrated that exogenous TGF-β1 can modulate otic chondrogenesis by acting as either an enhancer or a suppressor of this process. Our immunohistochemical and in vitro results suggest a paracrine action for this growth factor in modulation of epithelial-mesenchymal tissue interactions and otic morphogenesis.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalAnnals of Otology, Rhinology & Laryngology
Issue number4
StatePublished - Apr 1991


  • Chondrogenesis
  • Growth factor
  • Otic capsule formation
  • Otocyst
  • Periotic mesenchyme

ASJC Scopus subject areas

  • Otorhinolaryngology


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