Transforming Growth Factor Beta: A Biologic Chorioretinal Glue

William E. Smiddy, Bert M. Glaser, W. Richard Green, Thomas B. Connor, Anita B. Roberts, Michael B. Sporn, Roger Lucas

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Transforming growth factor beta (TGF-β) stimulates fibrosis. We studied its possible role as a bioactive substance for inducing localized chorioretinal wound healing along the edge of a retinal tear. The TGF-β was applied to induced retinal tears that were examined histopathologically. One day after surgery, neither control nor TGF-β-treated eyes developed chorioretinal wound healing. Four days, two weeks, and two months after surgery, the control eyes still had not developed chorioretinal wound healing. In contrast, the edges of the retinal tear treated with TGF-β were adherent to the underlying Bruch's membrane via localized fibrous tissue without apparent effects elsewhere. These results demonstrate intraocular in vivo bioactivity of TGF-β and suggest that TGF-β may have a potential role as an alternative means for inducing a chorioretinal adhesion in the treatment of retinal tears.

Original languageEnglish (US)
Pages (from-to)577-580
Number of pages4
JournalArchives of ophthalmology
Volume107
Issue number4
DOIs
StatePublished - Apr 1989

ASJC Scopus subject areas

  • Ophthalmology

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    Smiddy, W. E., Glaser, B. M., Green, W. R., Connor, T. B., Roberts, A. B., Sporn, M. B., & Lucas, R. (1989). Transforming Growth Factor Beta: A Biologic Chorioretinal Glue. Archives of ophthalmology, 107(4), 577-580. https://doi.org/10.1001/archopht.1989.01070010591036