Transforming growth factor-β2 significantly enhances the ability to flatten the rim of subretinal fluid surrounding macular holes: Preliminary anatomic results of a multicenter prospective randomized study

William E Smiddy, B. M. Glaser, J. T. Thompson, R. N. Sjaarda, Harry W Flynn, A. Hanham, R. P. Murphy

Research output: Contribution to journalArticle

121 Scopus citations


Previous studies of treatment of full-thickness macular holes have effected resolution of the surrounding subretinal fluid cuff in 58%-71% of cases. An initial report has found 330 ng and 1,330 ng transforming growth factor-β2 to be successful in effecting resolution of the surrounding subretinal fluid cuff in 100% of cases. A randomized, masked, controlled, prospective, multicenter study of 90 patients with full-thickness macular holes was performed to assess the efficacy of the local application of TGF- β2 at the time of vitrectomy surgery. Eligibility criteria included: (1) best corrected visual acuity of 20/80 or worse; (2) duration of macular hole for less than 1 year; and (3) absence of other ocular disorders that might interfere with vision. Patients were evenly randomized to receive placebo, 660 ng transforming growth factor-β2, or 1,330 ng transforming growth factor-β2. The treatment assignment was unmasked at the examination 3 months after treatment only if the macular hole failed to close. If the initial treatment had been placebo, patients were offered crossover to 1,330 ng transforming growth factor-β2 during a reoperation. It can be deduced that resolution of the subretinal fluid cuff occurred in 16 of 30 placebo- treated eyes, 53 of 58 eyes treated with transforming growth factor-β2, and in 9 of 13 cases (69%) initially treated with placebo that subsequently underwent repeat surgery under the crossover option. This preliminary report demonstrates that a single application of transforming growth factor-β2 has a statistically significant beneficial effect on resolution of the subretinal fluid cuff surrounding a macular hole when used in conjunction with standard vitrectomy for full-thickness macular holes.

Original languageEnglish
Pages (from-to)296-301
Number of pages6
Issue number4
StatePublished - Dec 1 1993
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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