Transformation of follicular lymphoma

Izidore S. Lossos, Randy D. Gascoyne

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


Histological transformation of follicular lymphoma (FL) to a more aggressive non-Hodgkin's lymphomas is a pivotal event in the natural history of FL and is associated with poor outcome. While commonly observed in clinical practice and despite multiple studies designed to address its pathogenesis, the biology of this process represents an enigma. In this chapter we present a state of the art review summarizing the definition of histologic transformation, its incidence, pathogenesis, clinical manifestations, treatment and outcome. Furthermore, we specifically emphasize gaps in our knowledge that should be addressed in future studies.

Original languageEnglish (US)
Pages (from-to)147-163
Number of pages17
JournalBest Practice and Research: Clinical Haematology
Issue number2
StatePublished - Jun 2011


  • follicular lymphoma
  • MYC
  • transformation
  • transplantation

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry


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