Transformation by herpesvirus saimiri

Sequences contained within the saimiri transformation- associated protein (STP) gene region of herpesvirus (h), saimiri strain plays an important and necessary role in cell growth transformation by the virus. These sequences are not required for replication of the virus. Many important aspects of the transformation process, however, have not been clarified. All herpesviruses typically persist in their natural hosts for prolonged periods, usually for life. The ability of some herpesviruses to immortalize the cells in which their genetic information resides could possibly facilitate their ability to persist in the host or to spread in the population. In some circumstances, this cell growth transformation can lead to the formation of tumors. A lymphotropic herpesvirus of nonhuman primates also immortalizes cells in vitro and induces tumors in animals. However, cell transformation and tumor induction are quite distinct from that of Epstein-Barr virus. It is hoped that the investigation of the transformation will lead to better understanding of fundamental mechanisms of herpesviral oncogenesis and signals for lymphocyte proliferation.