Transfer ribonucleic acid in hepatoma tissue culture cells. I. Induction in vivo by dexamethasone phosphate of phenylalanine-accepting activity

Stringner Sue Yang, Marc E. Lippman, E. Brad Thompson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A specific increase in phenylalanine chargeable tRNA brought about by the steroid dexamethasone phosphate was observed in Hepatoma Tissue Culture (HTC) cells in vivo. The increase in phenylalanine acceptor activity in steroid treated cells was not accompanied by changes in the intracellular phenylalanine pool, phenylalanine transport or gross increases in other species of tRNA and was dependent on de novo RNA synthesis. This increase in phenylalanine acceptor activity following steroid seems to be simultaneous with but separable from the induction of tyrosine aminotransferase.

Original languageEnglish (US)
Pages (from-to)254-261
Number of pages8
JournalEndocrinology
Volume94
Issue number1
DOIs
StatePublished - Jan 1974

ASJC Scopus subject areas

  • Endocrinology

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