Transfer ribonucleic acid in hepatoma tissue culture cells. I. Induction in vivo by dexamethasone phosphate of phenylalanine accepting activity

S. S. Yang, Marc E Lippman, E. B. Thompson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A specific increase in phenylalanine chargeable tRNA brought about by the steroid dexamethasone phosphate was observed in Hepatoma Tissue Culture (HTC) cells in vivo. The increase in phenylalanine acceptor activity in steroid treated cells was not accompanied by changes in the intracellular phenylalanine pool, phenylalanine transport or gross increases in other species of tRNA and was dependent on de novo RNA synthesis. This increase in phenylalanine acceptor activity following steroid seems to be simultaneous with but separable from the induction of tyrosine aminotransferase.

Original languageEnglish
Pages (from-to)254-261
Number of pages8
JournalEndocrinology
Volume94
Issue number1
StatePublished - Jan 1 1974
Externally publishedYes

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dexamethasone 21-phosphate
Transfer RNA
Phenylalanine
Hepatocellular Carcinoma
Cell Culture Techniques
Steroids
Tyrosine Transaminase
RNA

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Transfer ribonucleic acid in hepatoma tissue culture cells. I. Induction in vivo by dexamethasone phosphate of phenylalanine accepting activity. / Yang, S. S.; Lippman, Marc E; Thompson, E. B.

In: Endocrinology, Vol. 94, No. 1, 01.01.1974, p. 254-261.

Research output: Contribution to journalArticle

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