Transection of the pineal stalk produces convulsions in male Mongolian gerbils (Meriones unguiculatus)

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The pineal gland has been implicated in the regulation of epileptic-like seizures in gerbils. Pinealectomy of gerbils results in seizures which affect approximately 80% of the gerbils. Telencephalic catecholamine levels are depressed by pinealectomy in gerbils and it has been suggested that the reduced norepinephrine (NE) levels are responsible for initiating or facilitating these seizures. The present study found that pineal stalk transection produced convulsions in gerbils which were indistinguishable from pinealectomy-induced convulsions. Stalk transection also produced a depression (38%) in parietal cortex NE levels which was similar to a depression observed in pinealectomized gerbils (52%). These depressions in cortical NE levels were not observed in other brain regions, specifically the hippocampus or the amygdala. However, a decline (25%) in hypothalamic NE levels was observed after stalk transection. These results suggest that the signals responsible for pinealectomy-induced convulsions are carried by the pineal stalk and that pinealectomy produces regional, not global, reductions in NE content.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalEpilepsy Research
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Gerbillinae
Seizures
Norepinephrine
Telencephalon
Parietal Lobe
Pineal Gland
Amygdala
Catecholamines
Epilepsy
Hippocampus
Brain

Keywords

  • Convulsions
  • Gerbils
  • Norepinephrine
  • Pineal

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Transection of the pineal stalk produces convulsions in male Mongolian gerbils (Meriones unguiculatus). / Champney, Thomas.

In: Epilepsy Research, Vol. 4, No. 1, 01.01.1989, p. 14-19.

Research output: Contribution to journalArticle

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AB - The pineal gland has been implicated in the regulation of epileptic-like seizures in gerbils. Pinealectomy of gerbils results in seizures which affect approximately 80% of the gerbils. Telencephalic catecholamine levels are depressed by pinealectomy in gerbils and it has been suggested that the reduced norepinephrine (NE) levels are responsible for initiating or facilitating these seizures. The present study found that pineal stalk transection produced convulsions in gerbils which were indistinguishable from pinealectomy-induced convulsions. Stalk transection also produced a depression (38%) in parietal cortex NE levels which was similar to a depression observed in pinealectomized gerbils (52%). These depressions in cortical NE levels were not observed in other brain regions, specifically the hippocampus or the amygdala. However, a decline (25%) in hypothalamic NE levels was observed after stalk transection. These results suggest that the signals responsible for pinealectomy-induced convulsions are carried by the pineal stalk and that pinealectomy produces regional, not global, reductions in NE content.

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