Transdisciplinary approach to restore pancreatic islet function

Carmen Fotino, R. Damaris Molano, Camillo Ricordi, Antonello Pileggi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The focus of our research is on islet immunobiology. We are exploring novel strategies that could be of assistance in the treatment and prevention of type 1 diabetes, as well as in the restoration of metabolic control via transplantation of insulin producing cells (i.e., islet cells) the multiple facets of diabetes and β-cell replacement encompass different complementary disciplines, such as immunology, cell biology, pharmacology, and bioengineering, among others. Through their interaction and integration, a transdisciplinary dimension is needed in order to address and overcome all aspects of the complex puzzle toward a successful clinical translation of a biological cure for diabetes.

Original languageEnglish (US)
Pages (from-to)210-221
Number of pages12
JournalImmunologic Research
Volume57
Issue number1-3
DOIs
StatePublished - Dec 1 2013

Keywords

  • Adenosine (Ado)
  • ATP
  • Autoimmunity
  • Beta cell
  • Bioengineering
  • Bioluminiscence
  • CD39
  • CD73
  • Cell transplantation
  • Cellular therapies
  • Confocal microscopy
  • Diabetes
  • Diabetes mellitus
  • Engraftment
  • Hyperbaric oxygen therapy
  • Imaging
  • Immunotherapy
  • Implantable device
  • Inflammation
  • Innate immunity
  • Islet transplantation
  • Live imaging
  • Metabolic control
  • Noninvasive imaging
  • P2X7
  • Purinergic receptors
  • Rejection
  • Transplant microenvironment
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology

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