Abstract
The activities of cyclic nucleotide phosphohydrolase, an enzyme marker for oligodendrocytes, and glutamine synthetase, an enzyme marker for astrocytes, were studied at early (21 to 26) and late (82 to 88) cell passages. The activity of cyclic nucleotide phosphohydrolase was markedly high and that of glutamine synthetase was low in the early passages, but this relation was reversed in the late passages. These findings suggest a 'transdifferentiation' of C6 glial cells with passage in culture.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 179-181 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 208 |
| Issue number | 4440 |
| DOIs | |
| State | Published - Jan 1 1980 |
| Externally published | Yes |
ASJC Scopus subject areas
- General
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Cite this
Parker, K. K., Norenberg, M. D., & Vernadakis, A. (1980). "Transdifferentiation" of c6 glial cells in culture. Science, 208(4440), 179-181. https://doi.org/10.1126/science.6102413