"Transdifferentiation" of c6 glial cells in culture

Keith K. Parker; Michael D. Norenberg; Antonia Vernadakis

doi:10.1126/science.6102413

"Transdifferentiation" of c6 glial cells in culture

Keith K. Parker, Michael D. Norenberg, Antonia Vernadakis

Pathology

Research output: Contribution to journal › Article

150 Scopus citations

Abstract

The activities of cyclic nucleotide phosphohydrolase, an enzyme marker for oligodendrocytes, and glutamine synthetase, an enzyme marker for astrocytes, were studied at early (21 to 26) and late (82 to 88) cell passages. The activity of cyclic nucleotide phosphohydrolase was markedly high and that of glutamine synthetase was low in the early passages, but this relation was reversed in the late passages. These findings suggest a 'transdifferentiation' of C6 glial cells with passage in culture.

Original language	English (US)
Pages (from-to)	179-181
Number of pages	3
Journal	Science
Volume	208
Issue number	4440
DOIs	https://doi.org/10.1126/science.6102413
State	Published - Jan 1 1980

Fingerprint

ASJC Scopus subject areas

General

Cite this

Parker, K. K., Norenberg, M. D., & Vernadakis, A. (1980). "Transdifferentiation" of c6 glial cells in culture. Science, 208(4440), 179-181. https://doi.org/10.1126/science.6102413

@article{c2aca2741e074084997cc6b0e1c6e40e,

title = "{"}Transdifferentiation{"} of c6 glial cells in culture",

abstract = "The activities of cyclic nucleotide phosphohydrolase, an enzyme marker for oligodendrocytes, and glutamine synthetase, an enzyme marker for astrocytes, were studied at early (21 to 26) and late (82 to 88) cell passages. The activity of cyclic nucleotide phosphohydrolase was markedly high and that of glutamine synthetase was low in the early passages, but this relation was reversed in the late passages. These findings suggest a 'transdifferentiation' of C6 glial cells with passage in culture.",

author = "Parker, {Keith K.} and Norenberg, {Michael D.} and Antonia Vernadakis",

year = "1980",

month = jan,

day = "1",

doi = "10.1126/science.6102413",

language = "English (US)",

volume = "208",

pages = "179--181",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4440",

}

TY - JOUR

T1 - "Transdifferentiation" of c6 glial cells in culture

AU - Parker, Keith K.

AU - Norenberg, Michael D.

AU - Vernadakis, Antonia

PY - 1980/1/1

Y1 - 1980/1/1

N2 - The activities of cyclic nucleotide phosphohydrolase, an enzyme marker for oligodendrocytes, and glutamine synthetase, an enzyme marker for astrocytes, were studied at early (21 to 26) and late (82 to 88) cell passages. The activity of cyclic nucleotide phosphohydrolase was markedly high and that of glutamine synthetase was low in the early passages, but this relation was reversed in the late passages. These findings suggest a 'transdifferentiation' of C6 glial cells with passage in culture.

AB - The activities of cyclic nucleotide phosphohydrolase, an enzyme marker for oligodendrocytes, and glutamine synthetase, an enzyme marker for astrocytes, were studied at early (21 to 26) and late (82 to 88) cell passages. The activity of cyclic nucleotide phosphohydrolase was markedly high and that of glutamine synthetase was low in the early passages, but this relation was reversed in the late passages. These findings suggest a 'transdifferentiation' of C6 glial cells with passage in culture.

UR - http://www.scopus.com/inward/record.url?scp=0019224249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019224249&partnerID=8YFLogxK

U2 - 10.1126/science.6102413

DO - 10.1126/science.6102413

M3 - Article

C2 - 6102413

AN - SCOPUS:0019224249

VL - 208

SP - 179

EP - 181

JO - Science

JF - Science

SN - 0036-8075

IS - 4440

ER -

Access to Document

10.1126/science.6102413