TY - JOUR
T1 - "Transdifferentiation" of c6 glial cells in culture
AU - Parker, Keith K.
AU - Norenberg, Michael D.
AU - Vernadakis, Antonia
PY - 1980
Y1 - 1980
N2 - The activities of cyclic nucleotide phosphohydrolase, an enzyme marker for oligodendrocytes, and glutamine synthetase, an enzyme marker for astrocytes, were studied at early (21 to 26) and late (82 to 88) cell passages. The activity of cyclic nucleotide phosphohydrolase was markedly high and that of glutamine synthetase was low in the early passages, but this relation was reversed in the late passages. These findings suggest a 'transdifferentiation' of C6 glial cells with passage in culture.
AB - The activities of cyclic nucleotide phosphohydrolase, an enzyme marker for oligodendrocytes, and glutamine synthetase, an enzyme marker for astrocytes, were studied at early (21 to 26) and late (82 to 88) cell passages. The activity of cyclic nucleotide phosphohydrolase was markedly high and that of glutamine synthetase was low in the early passages, but this relation was reversed in the late passages. These findings suggest a 'transdifferentiation' of C6 glial cells with passage in culture.
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U2 - 10.1126/science.6102413
DO - 10.1126/science.6102413
M3 - Article
C2 - 6102413
AN - SCOPUS:0019224249
VL - 208
SP - 179
EP - 181
JO - Science
JF - Science
SN - 0036-8075
IS - 4440
ER -