Transdermal artelinic acid: An effective treatment for Plasmodium berghei- infected mice

D. L. Klayman, Arba L Ager, L. Fleckenstein, A. J. Lin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Artelinic acid, a derivative of the naturally occurring antimalarial artemisinin, has been incorporated into a gel suitable for transdermal administration. The formulation was tested for efficacy in Plasmodium berghei-infected mice for both curative and prophylactic properties by application to their partially denuded backs, beginning on days 3 and 0, respectively, after injection of parasitized erythrocytes. In the curative experiments, rapid elimination of the parasitemia and 60-day survival of five of five mice was achieved by dermal application of gel containing 0.9 mg of artelinic acid that was administered twice a day, beginning on day 3 after infection, for three days (total dosage of 270 mg/kg). In the prophylactic trials, the establishment of parasitemia was prevented and 60-day survival was achieved in five of five mice at a dose of 0.9 mg of artelinic acid administered twice a day, beginning on the day of inoculation, for two days (total dosage of 180 mg/kg). The transdermal medium, with or without drug, caused no topical or systemic toxicity.

Original languageEnglish (US)
Pages (from-to)602-607
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume45
Issue number5
StatePublished - 1991
Externally publishedYes

Fingerprint

Plasmodium berghei
Parasitemia
Gels
Cutaneous Administration
Antimalarials
Therapeutics
Erythrocytes
Skin
Injections
Infection
Pharmaceutical Preparations
artelinic acid

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Transdermal artelinic acid : An effective treatment for Plasmodium berghei- infected mice. / Klayman, D. L.; Ager, Arba L; Fleckenstein, L.; Lin, A. J.

In: American Journal of Tropical Medicine and Hygiene, Vol. 45, No. 5, 1991, p. 602-607.

Research output: Contribution to journalArticle

Klayman, D. L. ; Ager, Arba L ; Fleckenstein, L. ; Lin, A. J. / Transdermal artelinic acid : An effective treatment for Plasmodium berghei- infected mice. In: American Journal of Tropical Medicine and Hygiene. 1991 ; Vol. 45, No. 5. pp. 602-607.
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