Transdermal artelinic acid: An effective treatment for Plasmodium berghei- infected mice

D. L. Klayman, A. L. Ager, L. Fleckenstein, A. J. Lin

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Artelinic acid, a derivative of the naturally occurring antimalarial artemisinin, has been incorporated into a gel suitable for transdermal administration. The formulation was tested for efficacy in Plasmodium berghei-infected mice for both curative and prophylactic properties by application to their partially denuded backs, beginning on days 3 and 0, respectively, after injection of parasitized erythrocytes. In the curative experiments, rapid elimination of the parasitemia and 60-day survival of five of five mice was achieved by dermal application of gel containing 0.9 mg of artelinic acid that was administered twice a day, beginning on day 3 after infection, for three days (total dosage of 270 mg/kg). In the prophylactic trials, the establishment of parasitemia was prevented and 60-day survival was achieved in five of five mice at a dose of 0.9 mg of artelinic acid administered twice a day, beginning on the day of inoculation, for two days (total dosage of 180 mg/kg). The transdermal medium, with or without drug, caused no topical or systemic toxicity.

Original languageEnglish (US)
Pages (from-to)602-607
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume45
Issue number5
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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