Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model

Benjamin J. Harrison, Gayathri Venkat, Thomas Hutson, Kristofer K. Rau, Mary B Bunge, Lorne M. Mendell, Fred H. Gage, Richard D. Johnson, Caitlin Hill, Eric C. Rouchka, Lawrence Moon, Jeffrey C. Petruska

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Primary afferent collateral sprouting is a process whereby non-injured primary afferent neurons respond to some stimulus and extend new branches from existing axons. Neurons of both the central and peripheral nervous systems undergo this process, which contributes to both adaptive and maladaptive plasticity (e.g., [1-9]). In the model used here (the "spared dermatome" model), the intact sensory neurons respond to the denervation of adjacent areas of skin by sprouting new axon branches into that adjacent denervated territory. Investigations of gene expression changes associated with collateral sprouting can provide a better understanding of the molecular mechanisms controlling this process. Consequently, it can be used to develop treatments to promote functional recovery for spinal cord injury and other similar conditions. This report includes raw gene expression data files from microarray experiments in order to study the gene regulation in spared sensory ganglia in the initiation (7 days) and maintenance (14 days) phases of the spared dermatome model relative to intact ("naïve") sensory ganglia. Data has been deposited into GEO (GSE72551).

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalGenomics Data
Volume6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Sensory Ganglia
Gene expression
Neurons
Axons
Gene Expression
Afferent Neurons
Information Storage and Retrieval
Peripheral Nervous System
Denervation
Sensory Receptor Cells
Spinal Cord Injuries
Central Nervous System
Maintenance
Neurology
Microarrays
Skin
Plasticity
Genes
Recovery
Experiments

Keywords

  • Axon growth
  • Axonal plasticity
  • Nerve injury
  • Pain
  • Transcriptomics

ASJC Scopus subject areas

  • Molecular Medicine
  • Biochemistry
  • Biotechnology
  • Genetics

Cite this

Harrison, B. J., Venkat, G., Hutson, T., Rau, K. K., Bunge, M. B., Mendell, L. M., ... Petruska, J. C. (2015). Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model. Genomics Data, 6, 249-252. https://doi.org/10.1016/j.gdata.2015.10.005

Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model. / Harrison, Benjamin J.; Venkat, Gayathri; Hutson, Thomas; Rau, Kristofer K.; Bunge, Mary B; Mendell, Lorne M.; Gage, Fred H.; Johnson, Richard D.; Hill, Caitlin; Rouchka, Eric C.; Moon, Lawrence; Petruska, Jeffrey C.

In: Genomics Data, Vol. 6, 01.12.2015, p. 249-252.

Research output: Contribution to journalArticle

Harrison, BJ, Venkat, G, Hutson, T, Rau, KK, Bunge, MB, Mendell, LM, Gage, FH, Johnson, RD, Hill, C, Rouchka, EC, Moon, L & Petruska, JC 2015, 'Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model', Genomics Data, vol. 6, pp. 249-252. https://doi.org/10.1016/j.gdata.2015.10.005
Harrison, Benjamin J. ; Venkat, Gayathri ; Hutson, Thomas ; Rau, Kristofer K. ; Bunge, Mary B ; Mendell, Lorne M. ; Gage, Fred H. ; Johnson, Richard D. ; Hill, Caitlin ; Rouchka, Eric C. ; Moon, Lawrence ; Petruska, Jeffrey C. / Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model. In: Genomics Data. 2015 ; Vol. 6. pp. 249-252.
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