Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model

Benjamin J. Harrison, Gayathri Venkat, Thomas Hutson, Kristofer K. Rau, Mary Bartlett Bunge, Lorne M. Mendell, Fred H. Gage, Richard D. Johnson, Caitlin Hill, Eric C. Rouchka, Lawrence Moon, Jeffrey C. Petruska

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Primary afferent collateral sprouting is a process whereby non-injured primary afferent neurons respond to some stimulus and extend new branches from existing axons. Neurons of both the central and peripheral nervous systems undergo this process, which contributes to both adaptive and maladaptive plasticity (e.g., [1-9]). In the model used here (the "spared dermatome" model), the intact sensory neurons respond to the denervation of adjacent areas of skin by sprouting new axon branches into that adjacent denervated territory. Investigations of gene expression changes associated with collateral sprouting can provide a better understanding of the molecular mechanisms controlling this process. Consequently, it can be used to develop treatments to promote functional recovery for spinal cord injury and other similar conditions. This report includes raw gene expression data files from microarray experiments in order to study the gene regulation in spared sensory ganglia in the initiation (7 days) and maintenance (14 days) phases of the spared dermatome model relative to intact ("naïve") sensory ganglia. Data has been deposited into GEO (GSE72551).

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalGenomics Data
Volume6
DOIs
StatePublished - Dec 1 2015

Keywords

  • Axon growth
  • Axonal plasticity
  • Nerve injury
  • Pain
  • Transcriptomics

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Genetics

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  • Cite this

    Harrison, B. J., Venkat, G., Hutson, T., Rau, K. K., Bunge, M. B., Mendell, L. M., Gage, F. H., Johnson, R. D., Hill, C., Rouchka, E. C., Moon, L., & Petruska, J. C. (2015). Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model. Genomics Data, 6, 249-252. https://doi.org/10.1016/j.gdata.2015.10.005