Transcription factors in mature B-cells during aging

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The purpose of this chapter is to give an overview of the age-related changes in the expression and function of the major transcription factors regulating mature B-cells. We also summarize our recent work and show that the age-related defects in Ig class switch are directly related to the decrease in the transcription factor E47 which controls the expression of AID, needed for CSR. The age-associated effects on the expression and function of the transcription factors NF-κ B and Pax-5 are also described. Blimp-1 seems not to be modified by aging. For other transcription factors relevant for mature B-cell functions, such and IRF4 and Notch2, no effects of aging have been reported so far. The defects presented herein for aged B-cells should allow the discovery of mechanisms to improve humoral immune responses in both humans and mice in the near future.

Original languageEnglish
Title of host publicationHandbook on Immunosenescence: Basic Understanding and Clinical Applications
PublisherSpringer Netherlands
Pages381-391
Number of pages11
ISBN (Print)9781402090639, 9781402090622
DOIs
StatePublished - 2009

Fingerprint

Cell Aging
B-Lymphocytes
Transcription Factors
Paired Box Transcription Factors
Humoral Immunity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Frasca, D., Riley, R. L., & Blomberg, B. B. (2009). Transcription factors in mature B-cells during aging. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications (pp. 381-391). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9063-9-19

Transcription factors in mature B-cells during aging. / Frasca, Daniela; Riley, Richard L; Blomberg, Bonnie B.

Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, 2009. p. 381-391.

Research output: Chapter in Book/Report/Conference proceedingChapter

Frasca, D, Riley, RL & Blomberg, BB 2009, Transcription factors in mature B-cells during aging. in Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, pp. 381-391. https://doi.org/10.1007/978-1-4020-9063-9-19
Frasca D, Riley RL, Blomberg BB. Transcription factors in mature B-cells during aging. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands. 2009. p. 381-391 https://doi.org/10.1007/978-1-4020-9063-9-19
Frasca, Daniela ; Riley, Richard L ; Blomberg, Bonnie B. / Transcription factors in mature B-cells during aging. Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, 2009. pp. 381-391
@inbook{74740f782c4f4fab8f1c9d3cedcf81d6,
title = "Transcription factors in mature B-cells during aging",
abstract = "The purpose of this chapter is to give an overview of the age-related changes in the expression and function of the major transcription factors regulating mature B-cells. We also summarize our recent work and show that the age-related defects in Ig class switch are directly related to the decrease in the transcription factor E47 which controls the expression of AID, needed for CSR. The age-associated effects on the expression and function of the transcription factors NF-κ B and Pax-5 are also described. Blimp-1 seems not to be modified by aging. For other transcription factors relevant for mature B-cell functions, such and IRF4 and Notch2, no effects of aging have been reported so far. The defects presented herein for aged B-cells should allow the discovery of mechanisms to improve humoral immune responses in both humans and mice in the near future.",
author = "Daniela Frasca and Riley, {Richard L} and Blomberg, {Bonnie B}",
year = "2009",
doi = "10.1007/978-1-4020-9063-9-19",
language = "English",
isbn = "9781402090639",
pages = "381--391",
booktitle = "Handbook on Immunosenescence: Basic Understanding and Clinical Applications",
publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Transcription factors in mature B-cells during aging

AU - Frasca, Daniela

AU - Riley, Richard L

AU - Blomberg, Bonnie B

PY - 2009

Y1 - 2009

N2 - The purpose of this chapter is to give an overview of the age-related changes in the expression and function of the major transcription factors regulating mature B-cells. We also summarize our recent work and show that the age-related defects in Ig class switch are directly related to the decrease in the transcription factor E47 which controls the expression of AID, needed for CSR. The age-associated effects on the expression and function of the transcription factors NF-κ B and Pax-5 are also described. Blimp-1 seems not to be modified by aging. For other transcription factors relevant for mature B-cell functions, such and IRF4 and Notch2, no effects of aging have been reported so far. The defects presented herein for aged B-cells should allow the discovery of mechanisms to improve humoral immune responses in both humans and mice in the near future.

AB - The purpose of this chapter is to give an overview of the age-related changes in the expression and function of the major transcription factors regulating mature B-cells. We also summarize our recent work and show that the age-related defects in Ig class switch are directly related to the decrease in the transcription factor E47 which controls the expression of AID, needed for CSR. The age-associated effects on the expression and function of the transcription factors NF-κ B and Pax-5 are also described. Blimp-1 seems not to be modified by aging. For other transcription factors relevant for mature B-cell functions, such and IRF4 and Notch2, no effects of aging have been reported so far. The defects presented herein for aged B-cells should allow the discovery of mechanisms to improve humoral immune responses in both humans and mice in the near future.

UR - http://www.scopus.com/inward/record.url?scp=84919742312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919742312&partnerID=8YFLogxK

U2 - 10.1007/978-1-4020-9063-9-19

DO - 10.1007/978-1-4020-9063-9-19

M3 - Chapter

SN - 9781402090639

SN - 9781402090622

SP - 381

EP - 391

BT - Handbook on Immunosenescence: Basic Understanding and Clinical Applications

PB - Springer Netherlands

ER -