Transcription factors in mature B-cells during aging

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The purpose of this chapter is to give an overview of the age-related changes in the expression and function of the major transcription factors regulating mature B-cells. We also summarize our recent work and show that the age-related defects in Ig class switch are directly related to the decrease in the transcription factor E47 which controls the expression of AID, needed for CSR. The age-associated effects on the expression and function of the transcription factors NF-κ B and Pax-5 are also described. Blimp-1 seems not to be modified by aging. For other transcription factors relevant for mature B-cell functions, such and IRF4 and Notch2, no effects of aging have been reported so far. The defects presented herein for aged B-cells should allow the discovery of mechanisms to improve humoral immune responses in both humans and mice in the near future.

Original languageEnglish (US)
Title of host publicationHandbook on Immunosenescence
Subtitle of host publicationBasic Understanding and Clinical Applications
PublisherSpringer Netherlands
Pages381-391
Number of pages11
ISBN (Electronic)9781402090639
ISBN (Print)9781402090622
DOIs
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Medicine(all)

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    Frasca, D., Riley, R. L., & Blomberg, B. B. (2009). Transcription factors in mature B-cells during aging. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications (pp. 381-391). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9063-9-19