Transcription factor fusions in acute leukemia: Variations on a theme

Joseph M. Scandura, Piernicola Boccuni, Jorg Cammenga, Stephen D. Nimer

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for homo- or hetero-dimerization, and domains that interact with proteins involved in chromatin remodeling (e.g., corepressor molecules or co-activator molecules). It is these shared features that constitute the 'variations on the theme' that underling the aberrant growth and differentiation that is the hallmark of acute leukemia cells.

Original languageEnglish (US)
Pages (from-to)3422-3444
Number of pages23
JournalOncogene
Volume21
Issue number21 REV. ISS. 2
DOIs
StatePublished - May 13 2002
Externally publishedYes

Keywords

  • AMLI/ETO
  • CBFβ
  • Leukemia
  • NUP98
  • PML
  • RARaα
  • TGFβ
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Fingerprint Dive into the research topics of 'Transcription factor fusions in acute leukemia: Variations on a theme'. Together they form a unique fingerprint.

  • Cite this