Transcription factor fusions in acute leukemia: Variations on a theme

Joseph M. Scandura; Piernicola Boccuni; Jorg Cammenga; Stephen D. Nimer

doi:10.1038/sj.onc.1205315

Transcription factor fusions in acute leukemia: Variations on a theme

Joseph M. Scandura, Piernicola Boccuni, Jorg Cammenga, Stephen D. Nimer

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for homo- or hetero-dimerization, and domains that interact with proteins involved in chromatin remodeling (e.g., corepressor molecules or co-activator molecules). It is these shared features that constitute the 'variations on the theme' that underling the aberrant growth and differentiation that is the hallmark of acute leukemia cells.

Original language	English (US)
Pages (from-to)	3422-3444
Number of pages	23
Journal	Oncogene
Volume	21
Issue number	21 REV. ISS. 2
DOIs	https://doi.org/10.1038/sj.onc.1205315
State	Published - May 13 2002
Externally published	Yes

Keywords

AMLI/ETO
CBFβ
Leukemia
NUP98
PML
RARaα
TGFβ
Transcription

ASJC Scopus subject areas

Molecular Biology
Cancer Research
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.onc.1205315

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title = "Transcription factor fusions in acute leukemia: Variations on a theme",

abstract = "The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for homo- or hetero-dimerization, and domains that interact with proteins involved in chromatin remodeling (e.g., corepressor molecules or co-activator molecules). It is these shared features that constitute the 'variations on the theme' that underling the aberrant growth and differentiation that is the hallmark of acute leukemia cells.",

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author = "Scandura, {Joseph M.} and Piernicola Boccuni and Jorg Cammenga and Nimer, {Stephen D.}",

note = "Funding Information: We thank Ms Ellie Park for her assistance in preparing this manuscript for publication. This work was supported in part by NIH RO1 grant DK 52208 (SD Nimer), and by a Leukemia and Lymphoma Society SCOR grant (SD Nimer), a Clinical Scholars Award CA09512 from the NCI and the Charles A. Dana Foundation (JM Scandura), and by the Renny Saltzman Leukemia Research Fund (SD Nimer).",

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AU - Boccuni, Piernicola

AU - Cammenga, Jorg

AU - Nimer, Stephen D.

N1 - Funding Information: We thank Ms Ellie Park for her assistance in preparing this manuscript for publication. This work was supported in part by NIH RO1 grant DK 52208 (SD Nimer), and by a Leukemia and Lymphoma Society SCOR grant (SD Nimer), a Clinical Scholars Award CA09512 from the NCI and the Charles A. Dana Foundation (JM Scandura), and by the Renny Saltzman Leukemia Research Fund (SD Nimer).

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KW - Transcription

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Transcription factor fusions in acute leukemia: Variations on a theme

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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