During the last decades electrophysiological studies using transcranial magnetic stimulation (TMS) have demonstrated significant reorganization in the corticospinal system after human spinal cord injury (SCI). Evidence has shown that the latency and thresholds of motor evoked potentials (MEPs) elicited by TMS in upper and lower limb muscles are increased after SCI regardless of the time of injury. Electrophysiological studies indicated that corticospinal reorganization may contribute to aspects of functional recovery after SCI. Repetitive TMS has been used to induce long-lasting changes in corticospinal excitability and improvements in functional outcomes but their effect remains limited and inconsistent. Together, these studies revealed a large plastic capacity of the corticospinal system after SCI. Increasing our knowledge of the role of corticospinal plasticity in functional restoration after SCI may support the development of more effective therapeutic strategies.
|Original language||English (US)|
|Title of host publication||Cortical Connectivity: Brain Stimulation for Assessing and Modulating Cortical Connectivity and Function|
|Publisher||Springer-Verlag Berlin Heidelberg|
|Number of pages||14|
|ISBN (Print)||9783642327674, 3642327664, 9783642327667|
|State||Published - Jul 1 2012|
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