Transatlantic lipid guideline divergence: Same data but different interpretations

Carl E. Orringer, Lale Tokgozoglu, Kevin C. Maki, Kausik K. Ray, Joseph J. Saseen, Alberico L. Catapano

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Despite consensus that excessive circulating concentrations of apoB-lipoproteins is a key driver for the atherosclerotic process and that treatments that low-density lipoprotein cholesterol lowering by up-regulation of low-density lipoprotein cholesterol receptor expression reduces that risk, divergent viewpoints on interpretation of study data have resulted in substantial differences in European and American lipid guideline recommendations. This article explores those differences and highlights the importance of understanding guideline-based lipid management to improve patient care and reduce the risk of clinical atherosclerotic cardiovascular disease.

Original languageEnglish (US)
Article numbere018189
JournalJournal of the American Heart Association
Issue number21
StatePublished - Nov 3 2020


  • Guideline
  • Risk assessment
  • Therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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