Tramadol-induced seizurogenic effect: A possible role of opioid-dependent histamine (H1) receptor activation-linked mechanism

Ashish K. Rehni, Thakur Gurjeet Singh, Nirmal Singh, Sandeep Arora

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

The present study has been designed to investigate the role of opioid receptors, mast cells, and histamine receptors (H1 subtype) in the seizurogenic effect of tramadol on pentylenetetrazole-treated mice. A single injection of pentylenetetrazole (80 mg kg-1) was used to elicit seizure activity in mice. Seizures were assessed in terms of the time latency of the onset of Straub-like tail, onset of jerky movements of whole body, convulsions, and death. Tramadol administration (50 mg kg -1) caused a marked increase in seizurogenic activity of pentylenetetrazole as measured in terms of a significant decrease in the time latency of the onset of Straub-like tail, jerky movements of whole body, convulsions, and death. Moreover, prior administration of naloxone (2 mg kg-1), fexofenadine (100 mg kg -1), cetrizine, sodium cromoglycate, and ketotifen (10 mg kg -1), respectively, attenuated the seizurogenic activity that tramadol exerted on pentylenetetrazole-treated mice. Therefore, it may be suggested that tramadol exerts a seizurogenic effect on mice via an H1 receptor activation-linked pathway possibly through an opioid receptor-dependent release of histamine from the mast cells.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume381
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Histamine receptors
  • Mast cells
  • Opioid receptors
  • Seizures
  • Tramadol

ASJC Scopus subject areas

  • Pharmacology

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