TY - JOUR
T1 - Trajectories of Change and Intermediate Indicators of Non-Response to Transdiagnostic Treatment for Children and Adolescents
AU - Kennedy, Sarah M.
AU - Halliday, Elizabeth
AU - Ehrenreich-May, Jill
N1 - Funding Information:
Some of the data presented in this study was collected through a NIMH K23 Award to the third author [K23 MH073946].
Publisher Copyright:
© 2020 Society of Clinical Child & Adolescent Psychology.
PY - 2021
Y1 - 2021
N2 - Objective: In the current study, we sought to identify distinct trajectories of symptom change and mid-treatment tailoring variables for the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children (UP-C) and Adolescents (UP-A), with the goal of providing empirical data to guide the implementation of adaptive and personalized interventions using this approach. Method: Participants were 94 youth ages 7–17 (M = 13.36, 56.40% female) who completed the UP-C or UP-A. Participants received a diagnostic assessment at baseline and completed symptoms measures at mid-treatment and post-treatment assessments. Results: Growth mixture modeling revealed three distinct classes of responders based on youth-reported and parent-reported symptoms of anxiety and depression, with two of these classes exhibiting significant slope variability. Overall baseline global severity, age, and comorbid social anxiety were significantly associated with class membership, while gender and presence of a comorbid obsessive-compulsive spectrum disorder were marginally associated with class membership. An 8–12% reduction in emotion disorder symptoms best predicted likelihood of post-treatment response. Conclusions: Results enhance our understanding of trajectories of response to transdiagnostic treatment and help to inform the development and implementation of more streamlined and personalized treatment approaches.
AB - Objective: In the current study, we sought to identify distinct trajectories of symptom change and mid-treatment tailoring variables for the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children (UP-C) and Adolescents (UP-A), with the goal of providing empirical data to guide the implementation of adaptive and personalized interventions using this approach. Method: Participants were 94 youth ages 7–17 (M = 13.36, 56.40% female) who completed the UP-C or UP-A. Participants received a diagnostic assessment at baseline and completed symptoms measures at mid-treatment and post-treatment assessments. Results: Growth mixture modeling revealed three distinct classes of responders based on youth-reported and parent-reported symptoms of anxiety and depression, with two of these classes exhibiting significant slope variability. Overall baseline global severity, age, and comorbid social anxiety were significantly associated with class membership, while gender and presence of a comorbid obsessive-compulsive spectrum disorder were marginally associated with class membership. An 8–12% reduction in emotion disorder symptoms best predicted likelihood of post-treatment response. Conclusions: Results enhance our understanding of trajectories of response to transdiagnostic treatment and help to inform the development and implementation of more streamlined and personalized treatment approaches.
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U2 - 10.1080/15374416.2020.1716363
DO - 10.1080/15374416.2020.1716363
M3 - Article
C2 - 32027519
AN - SCOPUS:85079223346
VL - 50
SP - 904
EP - 918
JO - Journal of clinical child psychology
JF - Journal of clinical child psychology
SN - 1537-4416
IS - 6
ER -