Trafficking and differentiation of mesenchymal stem cells

Research output: Contribution to journalArticle

257 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) are a heterogeneous population of stem/progenitor cells with pluripotent capacity to differentiate into mesodermal and non-mesodermal cell lineages, including osteocytes, adipocytes, chondrocytes, myocytes, cardiomyocytes, fibroblasts, myofibroblasts, epithelial cells, and neurons. MSCs reside primarily in the bone marrow, but also exist in other sites such as adipose tissue, peripheral blood, cord blood, liver, and fetal tissues. When stimulated by specific signals, these cells can be released from their niche in the bone marrow into circulation and recruited to the target tissues where they undergo in situ differentiation and contribute to tissue regeneration and homeostasis. Several characteristics of MSCs, such as the potential to differentiate into multiple lineages and the ability to be expanded ex vivo while retaining their original lineage differentiation commitment, make these cells very interesting targets for potential therapeutic use in regenerative medicine and tissue engineering. The feasibility for transplantation of primary or engineered MSCs as cell-based therapy has been demonstrated. In this review, we summarize the current knowledge on the signals that control trafficking and differentiation of MSCs.

Original languageEnglish
Pages (from-to)984-991
Number of pages8
JournalJournal of Cellular Biochemistry
Volume106
Issue number6
DOIs
StatePublished - Apr 15 2009

Fingerprint

Stem cells
Mesenchymal Stromal Cells
Tissue
Stem Cells
Bone Marrow
Tissue homeostasis
Bone
Blood
Osteocytes
Regenerative Medicine
Myofibroblasts
Transplantation (surgical)
Therapeutic Uses
Cell Lineage
Tissue Engineering
Tissue regeneration
Chondrocytes
Cell- and Tissue-Based Therapy
Fetal Blood
Adipocytes

Keywords

  • Cell differentiation
  • Cell traffick
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Trafficking and differentiation of mesenchymal stem cells. / Liu, Zhao-Jun; Zhuge, Ying; Velazquez, Omaida C.

In: Journal of Cellular Biochemistry, Vol. 106, No. 6, 15.04.2009, p. 984-991.

Research output: Contribution to journalArticle

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