Tracheobronchial Circulation

Adam Wanner, Gabor Horvath

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter focuses on airway blood flow (Qaw) in asthma and chronic obstructive pulmonary disease (COPD), with a brief discussion of the normal airway circulation as background. Since the blood circulation typically participates in inflammatory processes at the tissue level, the vasculature of the tracheobronchial tree can be expected to undergo structural and functional changes in asthma and COPD, conditions that are associated with airway inflammation. There are distinct differences in the vascular abnormalities between asthma and COPD. The purpose of this chapter is to review the pathophysiological role of the tracheobronchial circulation in asthma and COPD and the vascular effects of pharmacologic interventions. The airway circulation, which derives its blood from the systemic circulation, is the principal vascular supply to the airway wall. Bronchial arteries usually arise from the aorta or intercostal arteries and form a peribronchial plexus surrounding the bronchial wall. Under physiological conditions, total bronchial blood flow comprises 0.5-1% of cardiac output. The major part of blood flow is distributed to the subepithelial tissues where the microvasculature comprises 10-20% of tissue volume. Subepithelial blood flow (Qaw) has been reported to range between 30 and 95 ml min-1 100 g wet tissue-1 in different species including in humans. Allergic and non-allergic inflammation is considered a major factor in the vascular changes that have been associated with asthma. The inflammatory mechanisms include the complex actions of inflammatory cells and mediators, neurotransmitters, and neuropeptides on vascular endothelial and smooth muscle cells. The main vascular manifestations are hyperemia, hyperpermeability, and edema formation.

Original languageEnglish
Title of host publicationAsthma and COPD
PublisherElsevier Ltd
Pages241-248
Number of pages8
ISBN (Print)9780123740014
DOIs
StatePublished - Dec 1 2009

Fingerprint

Asthma
Chronic Obstructive Pulmonary Disease
Blood Vessels
Blood Circulation
Bronchial Arteries
Inflammation
Hyperemia
Microvessels
Neuropeptides
Vascular Smooth Muscle
Cardiac Output
Smooth Muscle Myocytes
Neurotransmitter Agents
Aorta
Edema
Arteries

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

Wanner, A., & Horvath, G. (2009). Tracheobronchial Circulation. In Asthma and COPD (pp. 241-248). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-374001-4.00019-5

Tracheobronchial Circulation. / Wanner, Adam; Horvath, Gabor.

Asthma and COPD. Elsevier Ltd, 2009. p. 241-248.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wanner, A & Horvath, G 2009, Tracheobronchial Circulation. in Asthma and COPD. Elsevier Ltd, pp. 241-248. https://doi.org/10.1016/B978-0-12-374001-4.00019-5
Wanner A, Horvath G. Tracheobronchial Circulation. In Asthma and COPD. Elsevier Ltd. 2009. p. 241-248 https://doi.org/10.1016/B978-0-12-374001-4.00019-5
Wanner, Adam ; Horvath, Gabor. / Tracheobronchial Circulation. Asthma and COPD. Elsevier Ltd, 2009. pp. 241-248
@inbook{bc043c97e5ff4202bc75e320860f528f,
title = "Tracheobronchial Circulation",
abstract = "This chapter focuses on airway blood flow (Qaw) in asthma and chronic obstructive pulmonary disease (COPD), with a brief discussion of the normal airway circulation as background. Since the blood circulation typically participates in inflammatory processes at the tissue level, the vasculature of the tracheobronchial tree can be expected to undergo structural and functional changes in asthma and COPD, conditions that are associated with airway inflammation. There are distinct differences in the vascular abnormalities between asthma and COPD. The purpose of this chapter is to review the pathophysiological role of the tracheobronchial circulation in asthma and COPD and the vascular effects of pharmacologic interventions. The airway circulation, which derives its blood from the systemic circulation, is the principal vascular supply to the airway wall. Bronchial arteries usually arise from the aorta or intercostal arteries and form a peribronchial plexus surrounding the bronchial wall. Under physiological conditions, total bronchial blood flow comprises 0.5-1{\%} of cardiac output. The major part of blood flow is distributed to the subepithelial tissues where the microvasculature comprises 10-20{\%} of tissue volume. Subepithelial blood flow (Qaw) has been reported to range between 30 and 95 ml min-1 100 g wet tissue-1 in different species including in humans. Allergic and non-allergic inflammation is considered a major factor in the vascular changes that have been associated with asthma. The inflammatory mechanisms include the complex actions of inflammatory cells and mediators, neurotransmitters, and neuropeptides on vascular endothelial and smooth muscle cells. The main vascular manifestations are hyperemia, hyperpermeability, and edema formation.",
author = "Adam Wanner and Gabor Horvath",
year = "2009",
month = "12",
day = "1",
doi = "10.1016/B978-0-12-374001-4.00019-5",
language = "English",
isbn = "9780123740014",
pages = "241--248",
booktitle = "Asthma and COPD",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Tracheobronchial Circulation

AU - Wanner, Adam

AU - Horvath, Gabor

PY - 2009/12/1

Y1 - 2009/12/1

N2 - This chapter focuses on airway blood flow (Qaw) in asthma and chronic obstructive pulmonary disease (COPD), with a brief discussion of the normal airway circulation as background. Since the blood circulation typically participates in inflammatory processes at the tissue level, the vasculature of the tracheobronchial tree can be expected to undergo structural and functional changes in asthma and COPD, conditions that are associated with airway inflammation. There are distinct differences in the vascular abnormalities between asthma and COPD. The purpose of this chapter is to review the pathophysiological role of the tracheobronchial circulation in asthma and COPD and the vascular effects of pharmacologic interventions. The airway circulation, which derives its blood from the systemic circulation, is the principal vascular supply to the airway wall. Bronchial arteries usually arise from the aorta or intercostal arteries and form a peribronchial plexus surrounding the bronchial wall. Under physiological conditions, total bronchial blood flow comprises 0.5-1% of cardiac output. The major part of blood flow is distributed to the subepithelial tissues where the microvasculature comprises 10-20% of tissue volume. Subepithelial blood flow (Qaw) has been reported to range between 30 and 95 ml min-1 100 g wet tissue-1 in different species including in humans. Allergic and non-allergic inflammation is considered a major factor in the vascular changes that have been associated with asthma. The inflammatory mechanisms include the complex actions of inflammatory cells and mediators, neurotransmitters, and neuropeptides on vascular endothelial and smooth muscle cells. The main vascular manifestations are hyperemia, hyperpermeability, and edema formation.

AB - This chapter focuses on airway blood flow (Qaw) in asthma and chronic obstructive pulmonary disease (COPD), with a brief discussion of the normal airway circulation as background. Since the blood circulation typically participates in inflammatory processes at the tissue level, the vasculature of the tracheobronchial tree can be expected to undergo structural and functional changes in asthma and COPD, conditions that are associated with airway inflammation. There are distinct differences in the vascular abnormalities between asthma and COPD. The purpose of this chapter is to review the pathophysiological role of the tracheobronchial circulation in asthma and COPD and the vascular effects of pharmacologic interventions. The airway circulation, which derives its blood from the systemic circulation, is the principal vascular supply to the airway wall. Bronchial arteries usually arise from the aorta or intercostal arteries and form a peribronchial plexus surrounding the bronchial wall. Under physiological conditions, total bronchial blood flow comprises 0.5-1% of cardiac output. The major part of blood flow is distributed to the subepithelial tissues where the microvasculature comprises 10-20% of tissue volume. Subepithelial blood flow (Qaw) has been reported to range between 30 and 95 ml min-1 100 g wet tissue-1 in different species including in humans. Allergic and non-allergic inflammation is considered a major factor in the vascular changes that have been associated with asthma. The inflammatory mechanisms include the complex actions of inflammatory cells and mediators, neurotransmitters, and neuropeptides on vascular endothelial and smooth muscle cells. The main vascular manifestations are hyperemia, hyperpermeability, and edema formation.

UR - http://www.scopus.com/inward/record.url?scp=84882923513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882923513&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374001-4.00019-5

DO - 10.1016/B978-0-12-374001-4.00019-5

M3 - Chapter

AN - SCOPUS:84882923513

SN - 9780123740014

SP - 241

EP - 248

BT - Asthma and COPD

PB - Elsevier Ltd

ER -