Tracheal mucosal edema in hydrostatic pulmonary edema

Horst J. Baier, D. Onorato, J. Barker, A. Wanner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Airway edema has been described in heart failure, and, in animal experiments, airway narrowing was observed with elevated left atrial pressure (Pla). On the basis of double-indicator-dilution principles using helium and dimethylether, we were able to measure a water compartment of the tracheal mucosa (V(H2O)) in dogs. Hypervolemia with an attendant increase in Pla caused by infusion of 2 liters of dextran increased V(H2O) from 368 ± 71 (SE) to 794 ± 177 μl (P < 0.01). Pulmonary arterial wedge and central venous pressures (Pcv) rose concomitantly. Increases in pulmonary arterial wedge and Pcv by a left atrial balloon catheter produced similar increases in V(H2O), whereas increases in Pcv alone by a right atrial balloon did not increase V(H2O). Increasing V(H2O) by dextran infusion was associated with an increase in pulmonary resistance from 1.16 ± 0.19 to 2.15 ± 0.24 cmH2O · l-1 · s (P < 0.01). These observations show that fluid accumulation in the lung during pulmonary congestion also involves extraparenchymal airways and is related to Pla rather than right atrial pressure. This indicates that sufficient collateral drainage exists during right-sided but not left-sided pressure elevations.

Original languageEnglish (US)
Pages (from-to)352-356
Number of pages5
JournalJournal of applied physiology
Volume77
Issue number1
DOIs
StatePublished - Jan 1 1994

Keywords

  • airway mucosal edema
  • airway obstruction
  • pulmonary congestion

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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