Tracheal mucous velocity was measured by observing the motion of teflon discs across the tracheal mucosa through a fiberoptic bronchoscope. The average rate of movement in 14 adult patients with cystic fibrosis was 2.6 mm per min ± 3.3 SD, compared with 20.1 mm per min ± 6.3 SD in 20 normal subjects of the same age (P<0.001). This failure of mucociliary transport may play a role in the pathogenesis of the pulmonary disease in cystic fibrosis. Administration of a beta adrenergic agent, terbutaline, increased the average mucous velocity in the patients with cystic fibrosis (to 5.5 mm per min ± 3.6 SD, P<0.001) but not in control subjects. This observation has potential therapeutic significance.
|Title of host publication||AMER.REV.RESP.DIS.|
|Number of pages||6|
|State||Published - Dec 1 1975|
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