Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline

R. E. Wood, Adam Wanner, J. Hirsch, P. M. Farrell

Research output: Chapter in Book/Report/Conference proceedingChapter

91 Citations (Scopus)

Abstract

Tracheal mucous velocity was measured by observing the motion of teflon discs across the tracheal mucosa through a fiberoptic bronchoscope. The average rate of movement in 14 adult patients with cystic fibrosis was 2.6 mm per min ± 3.3 SD, compared with 20.1 mm per min ± 6.3 SD in 20 normal subjects of the same age (P<0.001). This failure of mucociliary transport may play a role in the pathogenesis of the pulmonary disease in cystic fibrosis. Administration of a beta adrenergic agent, terbutaline, increased the average mucous velocity in the patients with cystic fibrosis (to 5.5 mm per min ± 3.6 SD, P<0.001) but not in control subjects. This observation has potential therapeutic significance.

Original languageEnglish
Title of host publicationAMER.REV.RESP.DIS.
Pages733-738
Number of pages6
Volume111
Edition6
StatePublished - Dec 1 1975
Externally publishedYes

Fingerprint

Mucociliary Clearance
Terbutaline
Cystic Fibrosis
Bronchoscopes
Polytetrafluoroethylene
Adrenergic Agents
Lung Diseases
Mucous Membrane
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wood, R. E., Wanner, A., Hirsch, J., & Farrell, P. M. (1975). Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline. In AMER.REV.RESP.DIS. (6 ed., Vol. 111, pp. 733-738)

Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline. / Wood, R. E.; Wanner, Adam; Hirsch, J.; Farrell, P. M.

AMER.REV.RESP.DIS.. Vol. 111 6. ed. 1975. p. 733-738.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wood, RE, Wanner, A, Hirsch, J & Farrell, PM 1975, Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline. in AMER.REV.RESP.DIS.. 6 edn, vol. 111, pp. 733-738.
Wood RE, Wanner A, Hirsch J, Farrell PM. Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline. In AMER.REV.RESP.DIS.. 6 ed. Vol. 111. 1975. p. 733-738
Wood, R. E. ; Wanner, Adam ; Hirsch, J. ; Farrell, P. M. / Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline. AMER.REV.RESP.DIS.. Vol. 111 6. ed. 1975. pp. 733-738
@inbook{13142c0a6b9d492b9add321dc9fbf080,
title = "Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline",
abstract = "Tracheal mucous velocity was measured by observing the motion of teflon discs across the tracheal mucosa through a fiberoptic bronchoscope. The average rate of movement in 14 adult patients with cystic fibrosis was 2.6 mm per min ± 3.3 SD, compared with 20.1 mm per min ± 6.3 SD in 20 normal subjects of the same age (P<0.001). This failure of mucociliary transport may play a role in the pathogenesis of the pulmonary disease in cystic fibrosis. Administration of a beta adrenergic agent, terbutaline, increased the average mucous velocity in the patients with cystic fibrosis (to 5.5 mm per min ± 3.6 SD, P<0.001) but not in control subjects. This observation has potential therapeutic significance.",
author = "Wood, {R. E.} and Adam Wanner and J. Hirsch and Farrell, {P. M.}",
year = "1975",
month = "12",
day = "1",
language = "English",
volume = "111",
pages = "733--738",
booktitle = "AMER.REV.RESP.DIS.",
edition = "6",

}

TY - CHAP

T1 - Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline

AU - Wood, R. E.

AU - Wanner, Adam

AU - Hirsch, J.

AU - Farrell, P. M.

PY - 1975/12/1

Y1 - 1975/12/1

N2 - Tracheal mucous velocity was measured by observing the motion of teflon discs across the tracheal mucosa through a fiberoptic bronchoscope. The average rate of movement in 14 adult patients with cystic fibrosis was 2.6 mm per min ± 3.3 SD, compared with 20.1 mm per min ± 6.3 SD in 20 normal subjects of the same age (P<0.001). This failure of mucociliary transport may play a role in the pathogenesis of the pulmonary disease in cystic fibrosis. Administration of a beta adrenergic agent, terbutaline, increased the average mucous velocity in the patients with cystic fibrosis (to 5.5 mm per min ± 3.6 SD, P<0.001) but not in control subjects. This observation has potential therapeutic significance.

AB - Tracheal mucous velocity was measured by observing the motion of teflon discs across the tracheal mucosa through a fiberoptic bronchoscope. The average rate of movement in 14 adult patients with cystic fibrosis was 2.6 mm per min ± 3.3 SD, compared with 20.1 mm per min ± 6.3 SD in 20 normal subjects of the same age (P<0.001). This failure of mucociliary transport may play a role in the pathogenesis of the pulmonary disease in cystic fibrosis. Administration of a beta adrenergic agent, terbutaline, increased the average mucous velocity in the patients with cystic fibrosis (to 5.5 mm per min ± 3.6 SD, P<0.001) but not in control subjects. This observation has potential therapeutic significance.

UR - http://www.scopus.com/inward/record.url?scp=0016793255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016793255&partnerID=8YFLogxK

M3 - Chapter

VL - 111

SP - 733

EP - 738

BT - AMER.REV.RESP.DIS.

ER -