Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline

R. E. Wood, Adam Wanner, J. Hirsch, P. M. Farrell

Research output: Chapter in Book/Report/Conference proceedingChapter

91 Scopus citations

Abstract

Tracheal mucous velocity was measured by observing the motion of teflon discs across the tracheal mucosa through a fiberoptic bronchoscope. The average rate of movement in 14 adult patients with cystic fibrosis was 2.6 mm per min ± 3.3 SD, compared with 20.1 mm per min ± 6.3 SD in 20 normal subjects of the same age (P<0.001). This failure of mucociliary transport may play a role in the pathogenesis of the pulmonary disease in cystic fibrosis. Administration of a beta adrenergic agent, terbutaline, increased the average mucous velocity in the patients with cystic fibrosis (to 5.5 mm per min ± 3.6 SD, P<0.001) but not in control subjects. This observation has potential therapeutic significance.

Original languageEnglish
Title of host publicationAMER.REV.RESP.DIS.
Pages733-738
Number of pages6
Volume111
Edition6
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Wood, R. E., Wanner, A., Hirsch, J., & Farrell, P. M. (1975). Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline. In AMER.REV.RESP.DIS. (6 ed., Vol. 111, pp. 733-738)