Toxoplasma encephalitis in recent Haitian entrants

J. C. Chan, L. B. Moskowitz, J. Olivella, G. T. Hensley, R. L. Greenman, T. A. Hoffman

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Abstract

We evaluated clinical features of five cases of Toxoplasma encephalitis (TE) occurring in recent Haitian entrants into the United States. None of the patients had any underlying malignancy or known immunosuppressive therapy. Histopathologic findings of TE at autopsy were confirmed by peroxidase-antiperoxidase method. Four patients had an antecedent episode of disseminated tuberculosis and all five were receiving antituberculous therapy when neurologic manifestations of lethargy, seizures, and motor weakness first developed. These symptoms progressed into coma and death within 15 days. Peripheral lymphocytopenia was noted in all patients; three were anergic. Parenchymal lesions were identified by CT brain scans and total proteins were elevated in spinal fluid in all cases. TE appears to be a manifestation of the acquired immune deficiency syndrome in Haitians; it should be suspected in those with a febrile illness and multiple focal lesions of the central nervous system.

Original languageEnglish
Pages (from-to)1211-1215
Number of pages5
JournalSouthern Medical Journal
Volume76
Issue number10
StatePublished - Dec 1 1983
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Chan, J. C., Moskowitz, L. B., Olivella, J., Hensley, G. T., Greenman, R. L., & Hoffman, T. A. (1983). Toxoplasma encephalitis in recent Haitian entrants. Southern Medical Journal, 76(10), 1211-1215.