Toxicologic effects of a high dose of thymidine in mice

Eugene H. Herman, William Jordan, Bach Ardalan, Daniel S. Zaharko, Bruce J. Bolten, David A. Cooney

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF1 mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial blood pressure and heart rate fell precipitously and remained depressed for over 6 hr. During the experimental period, sedation and anuresis were also consistently observed in thymidine-treated mice. After a dose of 4.7 g/kg, millimolar plasma thymidine concentrations were maintained for 16 to 20 hr; by contrast, at a lower but nonlethal dose (3.8 g/kg), millimolar plasma thymidine concentrations were maintained for only 9 hr. It is suggested that sustained elevation of circulating thymidine in the range 1-10 mm for periods greater than 1 2 day may be associated with toxicity in mice.

Original languageEnglish (US)
Pages (from-to)443-446
Number of pages4
JournalToxicology and Applied Pharmacology
Volume56
Issue number3
DOIs
StatePublished - Dec 1980
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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    Herman, E. H., Jordan, W., Ardalan, B., Zaharko, D. S., Bolten, B. J., & Cooney, D. A. (1980). Toxicologic effects of a high dose of thymidine in mice. Toxicology and Applied Pharmacology, 56(3), 443-446. https://doi.org/10.1016/0041-008X(80)90078-2