Abstract
The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF1 mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial blood pressure and heart rate fell precipitously and remained depressed for over 6 hr. During the experimental period, sedation and anuresis were also consistently observed in thymidine-treated mice. After a dose of 4.7 g/kg, millimolar plasma thymidine concentrations were maintained for 16 to 20 hr; by contrast, at a lower but nonlethal dose (3.8 g/kg), millimolar plasma thymidine concentrations were maintained for only 9 hr. It is suggested that sustained elevation of circulating thymidine in the range 1-10 mm for periods greater than 1 2 day may be associated with toxicity in mice.
| Original language | English |
|---|---|
| Pages (from-to) | 443-446 |
| Number of pages | 4 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 56 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Toxicologic effects of a high dose of thymidine in mice. / Herman, Eugene H.; Jordan, William; Ardalan, Bach; Zaharko, Daniel S.; Bolten, Bruce J.; Cooney, David A.
In: Toxicology and Applied Pharmacology, Vol. 56, No. 3, 01.01.1980, p. 443-446.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toxicologic effects of a high dose of thymidine in mice
AU - Herman, Eugene H.
AU - Jordan, William
AU - Ardalan, Bach
AU - Zaharko, Daniel S.
AU - Bolten, Bruce J.
AU - Cooney, David A.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF1 mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial blood pressure and heart rate fell precipitously and remained depressed for over 6 hr. During the experimental period, sedation and anuresis were also consistently observed in thymidine-treated mice. After a dose of 4.7 g/kg, millimolar plasma thymidine concentrations were maintained for 16 to 20 hr; by contrast, at a lower but nonlethal dose (3.8 g/kg), millimolar plasma thymidine concentrations were maintained for only 9 hr. It is suggested that sustained elevation of circulating thymidine in the range 1-10 mm for periods greater than 1 2 day may be associated with toxicity in mice.
AB - The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF1 mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial blood pressure and heart rate fell precipitously and remained depressed for over 6 hr. During the experimental period, sedation and anuresis were also consistently observed in thymidine-treated mice. After a dose of 4.7 g/kg, millimolar plasma thymidine concentrations were maintained for 16 to 20 hr; by contrast, at a lower but nonlethal dose (3.8 g/kg), millimolar plasma thymidine concentrations were maintained for only 9 hr. It is suggested that sustained elevation of circulating thymidine in the range 1-10 mm for periods greater than 1 2 day may be associated with toxicity in mice.
UR - http://www.scopus.com/inward/record.url?scp=0019157848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019157848&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(80)90078-2
DO - 10.1016/0041-008X(80)90078-2
M3 - Article
C2 - 7222028
AN - SCOPUS:0019157848
VL - 56
SP - 443
EP - 446
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 3
ER -