Toxicologic effects of a high dose of thymidine in mice

Eugene H. Herman, William Jordan, Bach Ardalan, Daniel S. Zaharko, Bruce J. Bolten, David A. Cooney

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF1 mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial blood pressure and heart rate fell precipitously and remained depressed for over 6 hr. During the experimental period, sedation and anuresis were also consistently observed in thymidine-treated mice. After a dose of 4.7 g/kg, millimolar plasma thymidine concentrations were maintained for 16 to 20 hr; by contrast, at a lower but nonlethal dose (3.8 g/kg), millimolar plasma thymidine concentrations were maintained for only 9 hr. It is suggested that sustained elevation of circulating thymidine in the range 1-10 mm for periods greater than 1 2 day may be associated with toxicity in mice.

Original languageEnglish
Pages (from-to)443-446
Number of pages4
JournalToxicology and Applied Pharmacology
Volume56
Issue number3
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint

Thymidine
Plasmas
Arterial Pressure
Lethal Dose 50
Blood pressure
Toxicity
Heart Rate
Injections

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Herman, E. H., Jordan, W., Ardalan, B., Zaharko, D. S., Bolten, B. J., & Cooney, D. A. (1980). Toxicologic effects of a high dose of thymidine in mice. Toxicology and Applied Pharmacology, 56(3), 443-446. https://doi.org/10.1016/0041-008X(80)90078-2

Toxicologic effects of a high dose of thymidine in mice. / Herman, Eugene H.; Jordan, William; Ardalan, Bach; Zaharko, Daniel S.; Bolten, Bruce J.; Cooney, David A.

In: Toxicology and Applied Pharmacology, Vol. 56, No. 3, 01.01.1980, p. 443-446.

Research output: Contribution to journalArticle

Herman, EH, Jordan, W, Ardalan, B, Zaharko, DS, Bolten, BJ & Cooney, DA 1980, 'Toxicologic effects of a high dose of thymidine in mice', Toxicology and Applied Pharmacology, vol. 56, no. 3, pp. 443-446. https://doi.org/10.1016/0041-008X(80)90078-2
Herman, Eugene H. ; Jordan, William ; Ardalan, Bach ; Zaharko, Daniel S. ; Bolten, Bruce J. ; Cooney, David A. / Toxicologic effects of a high dose of thymidine in mice. In: Toxicology and Applied Pharmacology. 1980 ; Vol. 56, No. 3. pp. 443-446.
@article{ec274101ee304c519ac716fb75d5d2b5,
title = "Toxicologic effects of a high dose of thymidine in mice",
abstract = "The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF1 mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial blood pressure and heart rate fell precipitously and remained depressed for over 6 hr. During the experimental period, sedation and anuresis were also consistently observed in thymidine-treated mice. After a dose of 4.7 g/kg, millimolar plasma thymidine concentrations were maintained for 16 to 20 hr; by contrast, at a lower but nonlethal dose (3.8 g/kg), millimolar plasma thymidine concentrations were maintained for only 9 hr. It is suggested that sustained elevation of circulating thymidine in the range 1-10 mm for periods greater than 1 2 day may be associated with toxicity in mice.",
author = "Herman, {Eugene H.} and William Jordan and Bach Ardalan and Zaharko, {Daniel S.} and Bolten, {Bruce J.} and Cooney, {David A.}",
year = "1980",
month = "1",
day = "1",
doi = "10.1016/0041-008X(80)90078-2",
language = "English",
volume = "56",
pages = "443--446",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Toxicologic effects of a high dose of thymidine in mice

AU - Herman, Eugene H.

AU - Jordan, William

AU - Ardalan, Bach

AU - Zaharko, Daniel S.

AU - Bolten, Bruce J.

AU - Cooney, David A.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF1 mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial blood pressure and heart rate fell precipitously and remained depressed for over 6 hr. During the experimental period, sedation and anuresis were also consistently observed in thymidine-treated mice. After a dose of 4.7 g/kg, millimolar plasma thymidine concentrations were maintained for 16 to 20 hr; by contrast, at a lower but nonlethal dose (3.8 g/kg), millimolar plasma thymidine concentrations were maintained for only 9 hr. It is suggested that sustained elevation of circulating thymidine in the range 1-10 mm for periods greater than 1 2 day may be associated with toxicity in mice.

AB - The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF1 mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial blood pressure and heart rate fell precipitously and remained depressed for over 6 hr. During the experimental period, sedation and anuresis were also consistently observed in thymidine-treated mice. After a dose of 4.7 g/kg, millimolar plasma thymidine concentrations were maintained for 16 to 20 hr; by contrast, at a lower but nonlethal dose (3.8 g/kg), millimolar plasma thymidine concentrations were maintained for only 9 hr. It is suggested that sustained elevation of circulating thymidine in the range 1-10 mm for periods greater than 1 2 day may be associated with toxicity in mice.

UR - http://www.scopus.com/inward/record.url?scp=0019157848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019157848&partnerID=8YFLogxK

U2 - 10.1016/0041-008X(80)90078-2

DO - 10.1016/0041-008X(80)90078-2

M3 - Article

VL - 56

SP - 443

EP - 446

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 3

ER -