Toxic anterior segment syndrome: A review

Erick Hernandez-Bogantes, Alejandro Navas, Andrea Naranjo, Guillermo Amescua, Enrique O. Graue-Hernandez, Harry W Flynn, Ike Ahmed

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Toxic anterior segment syndrome is a surgical complication characterized by a noninfectious anterior chamber inflammatory reaction having multiple etiologies. The clinical signs (prominent limbus-to-limbus corneal edema, anterior chamber inflammation)and symptoms (decreased visual acuity, discomfort)generally occur within the first 12-48 hours after intraocular surgery. Most patients achieve good clinical and visual outcomes when there is a prompt clinical diagnosis and adequate treatment. We review the literature on toxic anterior segment syndrome, emphasizing its etiology, pathophysiology, and clinical and surgical management, as well as prognosis and sequelae. Our goal is to reduce the frequency of toxic anterior segment syndrome by highlighting the importance of prevention, early recognition, and distinguishing toxic anterior segment syndrome from infectious endophthalmitis.

Original languageEnglish (US)
JournalSurvey of Ophthalmology
StatePublished - Jan 1 2019


  • anterior segment inflammation
  • anterior uveitis
  • cataract surgery
  • corneal edema
  • hypopyon
  • intracameral solutions
  • sterile inflammation
  • sterilization
  • topical steroids
  • toxic anterior segment syndrome

ASJC Scopus subject areas

  • Ophthalmology


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