TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis

Stefan B. Ploner, Eric M. Moult, Woo Jhon Choi, Nadia K. Waheed, Byung Kun Lee, Eduardo A. Novais, Emily D. Cole, Benjamin Potsaid, Lennart Husvogt, Julia Schottenhamml, Andreas Maier, Philip J Rosenfeld, Jay S. Duker, Joachim Hornegger, James G. Fujimoto

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

PURPOSE:: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. METHODS:: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds interscan times. The resulting VISTA data were then mapped to a color space for display. RESULTS:: The authors evaluated the VISTA visualization algorithm in normal eyes (n = 2), nonproliferative diabetic retinopathy eyes (n = 6), proliferative diabetic retinopathy eyes (n = 3), geographic atrophy eyes (n = 4), and exudative age-related macular degeneration eyes (n = 2). All eyes showed blood flow speed variations, and all eyes with pathology showed abnormal blood flow speeds compared with controls. CONCLUSION:: The authors developed a novel method for mapping VISTA into a color display, allowing visualization of relative blood flow speeds. The method was found useful, in a small case series, for visualizing blood flow speeds in a variety of ocular diseases and serves as a step toward quantitative optical coherence tomography angiography.

Original languageEnglish (US)
JournalRetina
DOIs
StateAccepted/In press - Sep 28 2016

Fingerprint

Optical Coherence Tomography
Angiography
Pathology
Color
Diabetic Retinopathy
Geographic Atrophy
Eye Diseases
Information Systems

ASJC Scopus subject areas

  • Ophthalmology

Cite this

TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY : Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis. / Ploner, Stefan B.; Moult, Eric M.; Choi, Woo Jhon; Waheed, Nadia K.; Lee, Byung Kun; Novais, Eduardo A.; Cole, Emily D.; Potsaid, Benjamin; Husvogt, Lennart; Schottenhamml, Julia; Maier, Andreas; Rosenfeld, Philip J; Duker, Jay S.; Hornegger, Joachim; Fujimoto, James G.

In: Retina, 28.09.2016.

Research output: Contribution to journalArticle

Ploner, SB, Moult, EM, Choi, WJ, Waheed, NK, Lee, BK, Novais, EA, Cole, ED, Potsaid, B, Husvogt, L, Schottenhamml, J, Maier, A, Rosenfeld, PJ, Duker, JS, Hornegger, J & Fujimoto, JG 2016, 'TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis', Retina. https://doi.org/10.1097/IAE.0000000000001328
Ploner, Stefan B. ; Moult, Eric M. ; Choi, Woo Jhon ; Waheed, Nadia K. ; Lee, Byung Kun ; Novais, Eduardo A. ; Cole, Emily D. ; Potsaid, Benjamin ; Husvogt, Lennart ; Schottenhamml, Julia ; Maier, Andreas ; Rosenfeld, Philip J ; Duker, Jay S. ; Hornegger, Joachim ; Fujimoto, James G. / TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY : Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis. In: Retina. 2016.
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T2 - Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis

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AU - Moult, Eric M.

AU - Choi, Woo Jhon

AU - Waheed, Nadia K.

AU - Lee, Byung Kun

AU - Novais, Eduardo A.

AU - Cole, Emily D.

AU - Potsaid, Benjamin

AU - Husvogt, Lennart

AU - Schottenhamml, Julia

AU - Maier, Andreas

AU - Rosenfeld, Philip J

AU - Duker, Jay S.

AU - Hornegger, Joachim

AU - Fujimoto, James G.

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N2 - PURPOSE:: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. METHODS:: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds interscan times. The resulting VISTA data were then mapped to a color space for display. RESULTS:: The authors evaluated the VISTA visualization algorithm in normal eyes (n = 2), nonproliferative diabetic retinopathy eyes (n = 6), proliferative diabetic retinopathy eyes (n = 3), geographic atrophy eyes (n = 4), and exudative age-related macular degeneration eyes (n = 2). All eyes showed blood flow speed variations, and all eyes with pathology showed abnormal blood flow speeds compared with controls. CONCLUSION:: The authors developed a novel method for mapping VISTA into a color display, allowing visualization of relative blood flow speeds. The method was found useful, in a small case series, for visualizing blood flow speeds in a variety of ocular diseases and serves as a step toward quantitative optical coherence tomography angiography.

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