Abstract
PURPOSE:: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. METHODS:: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds interscan times. The resulting VISTA data were then mapped to a color space for display. RESULTS:: The authors evaluated the VISTA visualization algorithm in normal eyes (n = 2), nonproliferative diabetic retinopathy eyes (n = 6), proliferative diabetic retinopathy eyes (n = 3), geographic atrophy eyes (n = 4), and exudative age-related macular degeneration eyes (n = 2). All eyes showed blood flow speed variations, and all eyes with pathology showed abnormal blood flow speeds compared with controls. CONCLUSION:: The authors developed a novel method for mapping VISTA into a color display, allowing visualization of relative blood flow speeds. The method was found useful, in a small case series, for visualizing blood flow speeds in a variety of ocular diseases and serves as a step toward quantitative optical coherence tomography angiography.
| Original language | English (US) |
|---|---|
| Journal | Retina |
| DOIs | |
| State | Accepted/In press - Sep 28 2016 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY : Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis. / Ploner, Stefan B.; Moult, Eric M.; Choi, Woo Jhon; Waheed, Nadia K.; Lee, Byung Kun; Novais, Eduardo A.; Cole, Emily D.; Potsaid, Benjamin; Husvogt, Lennart; Schottenhamml, Julia; Maier, Andreas; Rosenfeld, Philip J; Duker, Jay S.; Hornegger, Joachim; Fujimoto, James G.
In: Retina, 28.09.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
T2 - Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis
AU - Ploner, Stefan B.
AU - Moult, Eric M.
AU - Choi, Woo Jhon
AU - Waheed, Nadia K.
AU - Lee, Byung Kun
AU - Novais, Eduardo A.
AU - Cole, Emily D.
AU - Potsaid, Benjamin
AU - Husvogt, Lennart
AU - Schottenhamml, Julia
AU - Maier, Andreas
AU - Rosenfeld, Philip J
AU - Duker, Jay S.
AU - Hornegger, Joachim
AU - Fujimoto, James G.
PY - 2016/9/28
Y1 - 2016/9/28
N2 - PURPOSE:: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. METHODS:: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds interscan times. The resulting VISTA data were then mapped to a color space for display. RESULTS:: The authors evaluated the VISTA visualization algorithm in normal eyes (n = 2), nonproliferative diabetic retinopathy eyes (n = 6), proliferative diabetic retinopathy eyes (n = 3), geographic atrophy eyes (n = 4), and exudative age-related macular degeneration eyes (n = 2). All eyes showed blood flow speed variations, and all eyes with pathology showed abnormal blood flow speeds compared with controls. CONCLUSION:: The authors developed a novel method for mapping VISTA into a color display, allowing visualization of relative blood flow speeds. The method was found useful, in a small case series, for visualizing blood flow speeds in a variety of ocular diseases and serves as a step toward quantitative optical coherence tomography angiography.
AB - PURPOSE:: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. METHODS:: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds interscan times. The resulting VISTA data were then mapped to a color space for display. RESULTS:: The authors evaluated the VISTA visualization algorithm in normal eyes (n = 2), nonproliferative diabetic retinopathy eyes (n = 6), proliferative diabetic retinopathy eyes (n = 3), geographic atrophy eyes (n = 4), and exudative age-related macular degeneration eyes (n = 2). All eyes showed blood flow speed variations, and all eyes with pathology showed abnormal blood flow speeds compared with controls. CONCLUSION:: The authors developed a novel method for mapping VISTA into a color display, allowing visualization of relative blood flow speeds. The method was found useful, in a small case series, for visualizing blood flow speeds in a variety of ocular diseases and serves as a step toward quantitative optical coherence tomography angiography.
UR - http://www.scopus.com/inward/record.url?scp=84989249031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84989249031&partnerID=8YFLogxK
U2 - 10.1097/IAE.0000000000001328
DO - 10.1097/IAE.0000000000001328
M3 - Article
C2 - 28005670
AN - SCOPUS:84989249031
JO - Retina
JF - Retina
SN - 0275-004X
ER -