Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy: Design and Implementation of the DCM Precision Medicine Study

Daniel D. Kinnamon, Ana Morales, Deborah J. Bowen, Wylie Burke, Ray E. Hershberger, Ana Morales, Deborah J. Bowen, Julie M. Gastier-Foster, Deborah A. Nickerson, Michael O. Dorschner, Garrie Haas, William Abraham, Philip Binkley, Ayesha Hasan, Jennifer Host, Brent Lampert, Sakima Smith, Gordon Huggins, David Denofrio, Michael KiernanDaniel Fishbein, Richard Cheng, Todd Dardas, Wayne Levy, Claudius Mahr, Sofia Masri, April Stempien-Otero, Stephen Gottlieb, Matthew Wheeler, Euan Ashley, Julia Platt, Mark Hofmeyer, Wilson Tang, Randall Starling, Rocio Moran, Anjali Owens, Kenneth Marguilies, Thomas Cappola, Lee Goldberg, Susan Brozena, J. Rame, Rhondalyn McLean, Charles Moore, Matthew Deshazo, Robert Long, Francisco Jimenez Carcamo, Hakop Hrachian-Haftevani, Barry Trachtenberg, Guhu Ashrith, Arvind Bhimarahj, Jerry Estep, Nancy Sweitzer, Carlos D. Bustamante, Gail P. Jarvik, Eden R Martin, Heidi Rehm, Patrice Desvigne-Nickens, James Troendle, Yi Ping Fu, Lucia Hindorff

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background - The cause of idiopathic dilated cardiomyopathy (DCM) is unknown by definition, but its familial subtype is considered to have a genetic component. We hypothesize that most idiopathic DCM, whether familial or nonfamilial, has a genetic basis, in which case a genetics-driven approach to identifying at-risk family members for clinical screening and early intervention could reduce morbidity and mortality. Methods - On the basis of this hypothesis, we have launched the National Heart, Lung, and Blood Institute- and National Human Genome Research Institute-funded DCM Precision Medicine Study, which aims to enroll 1300 individuals (600 non-Hispanic African ancestry, 600 non-Hispanic European ancestry, and 100 Hispanic) who meet rigorous clinical criteria for idiopathic DCM along with 2600 of their relatives. Enrolled relatives will undergo clinical cardiovascular screening to identify asymptomatic disease, and all individuals with idiopathic DCM will undergo exome sequencing to identify relevant variants in genes previously implicated in DCM. Results will be returned by genetic counselors 12 to 14 months after enrollment. The data obtained will be used to describe the prevalence of familial DCM among idiopathic DCM cases and the genetic architecture of idiopathic DCM in multiple ethnicity-ancestry groups. We will also conduct a randomized controlled trial to test the effectiveness of Family Heart Talk, an intervention to aid family communication, for improving uptake of preventive screening and surveillance in at-risk first-degree relatives. Conclusions - We anticipate that this study will demonstrate that idiopathic DCM has a genetic basis and guide best practices for a genetics-driven approach to early intervention in at-risk relatives. Clinical Trial Registration - URL: http://www.clinicaltrials.gov. Unique identifier: NCT03037632.

Original languageEnglish (US)
Article numbere001826
JournalCirculation: Cardiovascular Genetics
Volume10
Issue number6
DOIs
StatePublished - Dec 1 2017

Fingerprint

Precision Medicine
Dilated Cardiomyopathy
National Human Genome Research Institute (U.S.)
Exome
National Heart, Lung, and Blood Institute (U.S.)
Asymptomatic Diseases
Practice Guidelines
Hispanic Americans
Randomized Controlled Trials
Communication
Clinical Trials
Morbidity
Mortality

Keywords

  • communication
  • exome
  • genetics
  • morbidity
  • prevalence

ASJC Scopus subject areas

  • Genetics
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

Cite this

Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy : Design and Implementation of the DCM Precision Medicine Study. / Kinnamon, Daniel D.; Morales, Ana; Bowen, Deborah J.; Burke, Wylie; Hershberger, Ray E.; Morales, Ana; Bowen, Deborah J.; Gastier-Foster, Julie M.; Nickerson, Deborah A.; Dorschner, Michael O.; Haas, Garrie; Abraham, William; Binkley, Philip; Hasan, Ayesha; Host, Jennifer; Lampert, Brent; Smith, Sakima; Huggins, Gordon; Denofrio, David; Kiernan, Michael; Fishbein, Daniel; Cheng, Richard; Dardas, Todd; Levy, Wayne; Mahr, Claudius; Masri, Sofia; Stempien-Otero, April; Gottlieb, Stephen; Wheeler, Matthew; Ashley, Euan; Platt, Julia; Hofmeyer, Mark; Tang, Wilson; Starling, Randall; Moran, Rocio; Owens, Anjali; Marguilies, Kenneth; Cappola, Thomas; Goldberg, Lee; Brozena, Susan; Rame, J.; McLean, Rhondalyn; Moore, Charles; Deshazo, Matthew; Long, Robert; Jimenez Carcamo, Francisco; Hrachian-Haftevani, Hakop; Trachtenberg, Barry; Ashrith, Guhu; Bhimarahj, Arvind; Estep, Jerry; Sweitzer, Nancy; Bustamante, Carlos D.; Jarvik, Gail P.; Martin, Eden R; Rehm, Heidi; Desvigne-Nickens, Patrice; Troendle, James; Fu, Yi Ping; Hindorff, Lucia.

In: Circulation: Cardiovascular Genetics, Vol. 10, No. 6, e001826, 01.12.2017.

Research output: Contribution to journalArticle

Kinnamon, DD, Morales, A, Bowen, DJ, Burke, W, Hershberger, RE, Morales, A, Bowen, DJ, Gastier-Foster, JM, Nickerson, DA, Dorschner, MO, Haas, G, Abraham, W, Binkley, P, Hasan, A, Host, J, Lampert, B, Smith, S, Huggins, G, Denofrio, D, Kiernan, M, Fishbein, D, Cheng, R, Dardas, T, Levy, W, Mahr, C, Masri, S, Stempien-Otero, A, Gottlieb, S, Wheeler, M, Ashley, E, Platt, J, Hofmeyer, M, Tang, W, Starling, R, Moran, R, Owens, A, Marguilies, K, Cappola, T, Goldberg, L, Brozena, S, Rame, J, McLean, R, Moore, C, Deshazo, M, Long, R, Jimenez Carcamo, F, Hrachian-Haftevani, H, Trachtenberg, B, Ashrith, G, Bhimarahj, A, Estep, J, Sweitzer, N, Bustamante, CD, Jarvik, GP, Martin, ER, Rehm, H, Desvigne-Nickens, P, Troendle, J, Fu, YP & Hindorff, L 2017, 'Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy: Design and Implementation of the DCM Precision Medicine Study', Circulation: Cardiovascular Genetics, vol. 10, no. 6, e001826. https://doi.org/10.1161/CIRCGENETICS.117.001826
Kinnamon, Daniel D. ; Morales, Ana ; Bowen, Deborah J. ; Burke, Wylie ; Hershberger, Ray E. ; Morales, Ana ; Bowen, Deborah J. ; Gastier-Foster, Julie M. ; Nickerson, Deborah A. ; Dorschner, Michael O. ; Haas, Garrie ; Abraham, William ; Binkley, Philip ; Hasan, Ayesha ; Host, Jennifer ; Lampert, Brent ; Smith, Sakima ; Huggins, Gordon ; Denofrio, David ; Kiernan, Michael ; Fishbein, Daniel ; Cheng, Richard ; Dardas, Todd ; Levy, Wayne ; Mahr, Claudius ; Masri, Sofia ; Stempien-Otero, April ; Gottlieb, Stephen ; Wheeler, Matthew ; Ashley, Euan ; Platt, Julia ; Hofmeyer, Mark ; Tang, Wilson ; Starling, Randall ; Moran, Rocio ; Owens, Anjali ; Marguilies, Kenneth ; Cappola, Thomas ; Goldberg, Lee ; Brozena, Susan ; Rame, J. ; McLean, Rhondalyn ; Moore, Charles ; Deshazo, Matthew ; Long, Robert ; Jimenez Carcamo, Francisco ; Hrachian-Haftevani, Hakop ; Trachtenberg, Barry ; Ashrith, Guhu ; Bhimarahj, Arvind ; Estep, Jerry ; Sweitzer, Nancy ; Bustamante, Carlos D. ; Jarvik, Gail P. ; Martin, Eden R ; Rehm, Heidi ; Desvigne-Nickens, Patrice ; Troendle, James ; Fu, Yi Ping ; Hindorff, Lucia. / Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy : Design and Implementation of the DCM Precision Medicine Study. In: Circulation: Cardiovascular Genetics. 2017 ; Vol. 10, No. 6.
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abstract = "Background - The cause of idiopathic dilated cardiomyopathy (DCM) is unknown by definition, but its familial subtype is considered to have a genetic component. We hypothesize that most idiopathic DCM, whether familial or nonfamilial, has a genetic basis, in which case a genetics-driven approach to identifying at-risk family members for clinical screening and early intervention could reduce morbidity and mortality. Methods - On the basis of this hypothesis, we have launched the National Heart, Lung, and Blood Institute- and National Human Genome Research Institute-funded DCM Precision Medicine Study, which aims to enroll 1300 individuals (600 non-Hispanic African ancestry, 600 non-Hispanic European ancestry, and 100 Hispanic) who meet rigorous clinical criteria for idiopathic DCM along with 2600 of their relatives. Enrolled relatives will undergo clinical cardiovascular screening to identify asymptomatic disease, and all individuals with idiopathic DCM will undergo exome sequencing to identify relevant variants in genes previously implicated in DCM. Results will be returned by genetic counselors 12 to 14 months after enrollment. The data obtained will be used to describe the prevalence of familial DCM among idiopathic DCM cases and the genetic architecture of idiopathic DCM in multiple ethnicity-ancestry groups. We will also conduct a randomized controlled trial to test the effectiveness of Family Heart Talk, an intervention to aid family communication, for improving uptake of preventive screening and surveillance in at-risk first-degree relatives. Conclusions - We anticipate that this study will demonstrate that idiopathic DCM has a genetic basis and guide best practices for a genetics-driven approach to early intervention in at-risk relatives. Clinical Trial Registration - URL: http://www.clinicaltrials.gov. Unique identifier: NCT03037632.",
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T1 - Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy

T2 - Design and Implementation of the DCM Precision Medicine Study

AU - Kinnamon, Daniel D.

AU - Morales, Ana

AU - Bowen, Deborah J.

AU - Burke, Wylie

AU - Hershberger, Ray E.

AU - Morales, Ana

AU - Bowen, Deborah J.

AU - Gastier-Foster, Julie M.

AU - Nickerson, Deborah A.

AU - Dorschner, Michael O.

AU - Haas, Garrie

AU - Abraham, William

AU - Binkley, Philip

AU - Hasan, Ayesha

AU - Host, Jennifer

AU - Lampert, Brent

AU - Smith, Sakima

AU - Huggins, Gordon

AU - Denofrio, David

AU - Kiernan, Michael

AU - Fishbein, Daniel

AU - Cheng, Richard

AU - Dardas, Todd

AU - Levy, Wayne

AU - Mahr, Claudius

AU - Masri, Sofia

AU - Stempien-Otero, April

AU - Gottlieb, Stephen

AU - Wheeler, Matthew

AU - Ashley, Euan

AU - Platt, Julia

AU - Hofmeyer, Mark

AU - Tang, Wilson

AU - Starling, Randall

AU - Moran, Rocio

AU - Owens, Anjali

AU - Marguilies, Kenneth

AU - Cappola, Thomas

AU - Goldberg, Lee

AU - Brozena, Susan

AU - Rame, J.

AU - McLean, Rhondalyn

AU - Moore, Charles

AU - Deshazo, Matthew

AU - Long, Robert

AU - Jimenez Carcamo, Francisco

AU - Hrachian-Haftevani, Hakop

AU - Trachtenberg, Barry

AU - Ashrith, Guhu

AU - Bhimarahj, Arvind

AU - Estep, Jerry

AU - Sweitzer, Nancy

AU - Bustamante, Carlos D.

AU - Jarvik, Gail P.

AU - Martin, Eden R

AU - Rehm, Heidi

AU - Desvigne-Nickens, Patrice

AU - Troendle, James

AU - Fu, Yi Ping

AU - Hindorff, Lucia

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background - The cause of idiopathic dilated cardiomyopathy (DCM) is unknown by definition, but its familial subtype is considered to have a genetic component. We hypothesize that most idiopathic DCM, whether familial or nonfamilial, has a genetic basis, in which case a genetics-driven approach to identifying at-risk family members for clinical screening and early intervention could reduce morbidity and mortality. Methods - On the basis of this hypothesis, we have launched the National Heart, Lung, and Blood Institute- and National Human Genome Research Institute-funded DCM Precision Medicine Study, which aims to enroll 1300 individuals (600 non-Hispanic African ancestry, 600 non-Hispanic European ancestry, and 100 Hispanic) who meet rigorous clinical criteria for idiopathic DCM along with 2600 of their relatives. Enrolled relatives will undergo clinical cardiovascular screening to identify asymptomatic disease, and all individuals with idiopathic DCM will undergo exome sequencing to identify relevant variants in genes previously implicated in DCM. Results will be returned by genetic counselors 12 to 14 months after enrollment. The data obtained will be used to describe the prevalence of familial DCM among idiopathic DCM cases and the genetic architecture of idiopathic DCM in multiple ethnicity-ancestry groups. We will also conduct a randomized controlled trial to test the effectiveness of Family Heart Talk, an intervention to aid family communication, for improving uptake of preventive screening and surveillance in at-risk first-degree relatives. Conclusions - We anticipate that this study will demonstrate that idiopathic DCM has a genetic basis and guide best practices for a genetics-driven approach to early intervention in at-risk relatives. Clinical Trial Registration - URL: http://www.clinicaltrials.gov. Unique identifier: NCT03037632.

AB - Background - The cause of idiopathic dilated cardiomyopathy (DCM) is unknown by definition, but its familial subtype is considered to have a genetic component. We hypothesize that most idiopathic DCM, whether familial or nonfamilial, has a genetic basis, in which case a genetics-driven approach to identifying at-risk family members for clinical screening and early intervention could reduce morbidity and mortality. Methods - On the basis of this hypothesis, we have launched the National Heart, Lung, and Blood Institute- and National Human Genome Research Institute-funded DCM Precision Medicine Study, which aims to enroll 1300 individuals (600 non-Hispanic African ancestry, 600 non-Hispanic European ancestry, and 100 Hispanic) who meet rigorous clinical criteria for idiopathic DCM along with 2600 of their relatives. Enrolled relatives will undergo clinical cardiovascular screening to identify asymptomatic disease, and all individuals with idiopathic DCM will undergo exome sequencing to identify relevant variants in genes previously implicated in DCM. Results will be returned by genetic counselors 12 to 14 months after enrollment. The data obtained will be used to describe the prevalence of familial DCM among idiopathic DCM cases and the genetic architecture of idiopathic DCM in multiple ethnicity-ancestry groups. We will also conduct a randomized controlled trial to test the effectiveness of Family Heart Talk, an intervention to aid family communication, for improving uptake of preventive screening and surveillance in at-risk first-degree relatives. Conclusions - We anticipate that this study will demonstrate that idiopathic DCM has a genetic basis and guide best practices for a genetics-driven approach to early intervention in at-risk relatives. Clinical Trial Registration - URL: http://www.clinicaltrials.gov. Unique identifier: NCT03037632.

KW - communication

KW - exome

KW - genetics

KW - morbidity

KW - prevalence

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