Tourette's disorder

Gholson J. Lyon, David Shprecher, Barbara Coffey, Roger Kurlan

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Tourette's disorder (TD) is a common childhood-onset neuropsychiatric disorder characterized by chronic motor and vocal tics. TD frequently occurs with other neuropsychiatric disorders, such as attention deficit hyperactivity disorder (ADHD) and obsessivecompulsive disorder (OCD), and may contribute to reduced quality of life and disability. Currently available treatments to reduce tics are limited by variable clinical response and frequent adverse effects. They include alpha-2 agonists, antipsychotics (first and second generation), tetrabenazine, benzodiazepines, and habit reversal therapy. Some new and emerging (but unproven) treatments are also discussed, including topiramate and dopamine agonists. In addition, there is increasing interest in deep brain stimulation, but this is not yet ready for general use.

Original languageEnglish (US)
Pages (from-to)274-286
Number of pages13
JournalCurrent Treatment Options in Neurology
Volume12
Issue number4
DOIs
StatePublished - Jul 2010
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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