Total PSA and free PSA in patients with severe liver dysfunction

Rama Devi Mittal, Mahendra Kumar Singh, Charles Selvaraju, Gourdas Choudhuri

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objectives: To evaluate the effect of liver diseases in patients, on serum free prostate specific antigen (fPSA) levels, total prostate specific antigen (tPSA) levels and fPSA/tPSA ratios. Methods: Serum concentrations of total and free as well as fPSA/tPSA were determined in 20 men with histologically confirmed liver cirrhosis, 15 men with chronic hepatitis and 20 healthy men. Results: The serum levels of total PSA in liver cirrhosis as well as in chronic hepatitis were significantly lower than those observed in control. Free PSA remained unchanged. Conclusions: Our study suggests that despite severe liver dysfunction the tPSA, fPSA as well as the ratio of fPSA/ tPSA were not elevated as it was hypothesized that liver impairment might affect the PSA levels, as liver is a site for PSA metabolism.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalIndian Journal of Urology
Issue number2
StatePublished - Apr 1 2003
Externally publishedYes


  • Chronic hepatitis
  • Free PSA
  • Liver cirrhosis
  • Total PSA

ASJC Scopus subject areas

  • Urology


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