Total homocysteine and cognition in a tri-ethnic cohort

The Northern Manhattan Study

Clinton B Wright, H. S. Lee, M. C. Paik, S. P. Stabler, R. H. Allen, Ralph L Sacco

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Objective: Several studies implicate elevated homocysteine as a risk factor for dementia and cognitive decline, but most studies have involved subjects older than 55 years from homogeneous populations. The authors examined homocysteine and cognition in a tri-ethnic community sample 40 years and older. Method: The Northern Manhattan Study includes 3,298 stroke-free subjects. Of these 2,871 had baseline fasting total homocysteine (tHcy) levels and Mini-Mental State Examination (MMSE) scores available. The authors used multiple linear regression to examine the cross-sectional association between baseline tHcy levels and mean MMSE scores adjusting for sociodemographic and vascular risk factors. Results: Homocysteine levels were related to age, renal function, and B12 deficiency. Those with B12 deficiency had tHcy levels five points higher (9.4 vs 14.4 nmol/L). Mean MMSE scores differed by age, sex, and race-ethnic group. Those with hypertension, diabetes, cardiac disease, and B12 deficiency had lower MMSE scores. In multivariate analyses, elevated tHcy was associated with lower mean MMSE scores for those older than 65 but not for those 40 to 64. Adjusting for B12 deficiency and sociodemographic factors the mean MMSE was 2.2 points lower for each unit increase in the log tHcy level (95% CI -3.6, -0.9). Adding vascular risk factors to the model did not attenuate this effect (mean MMSE -2.2 points; 95% CI -3.5, -0.9). Conclusions: Elevated homocysteine was independently associated with decreased cognition in subjects older than 65 in this tri-ethnic cohort, adjusting for sociodemographic and vascular risk factors.

Original languageEnglish
Pages (from-to)254-260
Number of pages7
JournalNeurology
Volume63
Issue number2
StatePublished - Jul 27 2004
Externally publishedYes

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Homocysteine
Cognition
Ethnic Groups
Dementia
Linear Models
Heart Diseases
Fasting
Multivariate Analysis
Stroke
Hypertension
Kidney

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wright, C. B., Lee, H. S., Paik, M. C., Stabler, S. P., Allen, R. H., & Sacco, R. L. (2004). Total homocysteine and cognition in a tri-ethnic cohort: The Northern Manhattan Study. Neurology, 63(2), 254-260.

Total homocysteine and cognition in a tri-ethnic cohort : The Northern Manhattan Study. / Wright, Clinton B; Lee, H. S.; Paik, M. C.; Stabler, S. P.; Allen, R. H.; Sacco, Ralph L.

In: Neurology, Vol. 63, No. 2, 27.07.2004, p. 254-260.

Research output: Contribution to journalArticle

Wright, CB, Lee, HS, Paik, MC, Stabler, SP, Allen, RH & Sacco, RL 2004, 'Total homocysteine and cognition in a tri-ethnic cohort: The Northern Manhattan Study', Neurology, vol. 63, no. 2, pp. 254-260.
Wright CB, Lee HS, Paik MC, Stabler SP, Allen RH, Sacco RL. Total homocysteine and cognition in a tri-ethnic cohort: The Northern Manhattan Study. Neurology. 2004 Jul 27;63(2):254-260.
Wright, Clinton B ; Lee, H. S. ; Paik, M. C. ; Stabler, S. P. ; Allen, R. H. ; Sacco, Ralph L. / Total homocysteine and cognition in a tri-ethnic cohort : The Northern Manhattan Study. In: Neurology. 2004 ; Vol. 63, No. 2. pp. 254-260.
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