Total, Dialyzable, and Nondialyzable Postabsorptive Hydroxyproline: Values in Patients With Cancer

Harvey B. Niell, Genaro M. Palmieri, Charles L. Neely, Theresa A. Maxwell, Stanley C. Hopkins, Mark S. Soloway

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The postabsorptive urinary total (T), dialyzable (D), and nondialyzable (ND) hydroxyproline (HYPRO) tests were evaluated to determine whether the patterns of excretion varied according to the predominance of osteoblastic v osteolytic bone involvement in 58 patients with neoplastic disease. In patients with osteolytic lesions from multiple myeloma, elevated T and D levels with normal ND HYPRO values were observed, along with elevated D/ND ratios. In prostate cancer, the T, D, and ND values were all elevated and the D/ND ratio was normal. Patients with Hodgkin's disease had elevated T, D, and ND HYPRO levels, and the D/ND ratio was in the range of patients with prostate cancer. The data suggest that these collagen markers may be useful in the long-term evaluation of these neoplasms in patients.

Original languageEnglish (US)
Pages (from-to)1925-1927
Number of pages3
JournalArchives of Internal Medicine
Volume143
Issue number10
DOIs
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine

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    Niell, H. B., Palmieri, G. M., Neely, C. L., Maxwell, T. A., Hopkins, S. C., & Soloway, M. S. (1983). Total, Dialyzable, and Nondialyzable Postabsorptive Hydroxyproline: Values in Patients With Cancer. Archives of Internal Medicine, 143(10), 1925-1927. https://doi.org/10.1001/archinte.1983.00350100097020