Total, dialyzable, and nondialyzable postabsorptive hydroxyproline. Values in patients with cancer

H. B. Niell; G. M. Palmieri; C. L. Neely; T. A. Maxwell; S. C. Hopkins; M. S. Soloway

doi:10.1001/archinte.143.10.1925

Total, dialyzable, and nondialyzable postabsorptive hydroxyproline. Values in patients with cancer

H. B. Niell, G. M. Palmieri, C. L. Neely, T. A. Maxwell, S. C. Hopkins, M. S. Soloway

Research output: Contribution to journal › Article › peer-review

Abstract

The postabsorptive urinary total (T), dialyzable (D), and nondialyzable (ND) hydroxyproline (HYPRO) tests were evaluated to determine whether the patterns of excretion varied according to the predominance of osteoblastic v osteolytic bone involvement in 58 patients with neoplastic disease. In patients with osteolytic lesions from multiple myeloma, elevated T and D levels with normal ND HYPRO values were observed, along with elevated D/ND ratios. In prostate cancer, the T, D, and ND values were all elevated and the D/ND ratio was normal. Patients with Hodgkin's disease had elevated T, D, and ND HYPRO levels, and the D/ND ratio was in the range of patients with prostate cancer. The data suggest that these collagen markers may be useful in the long-term evaluation of these neoplasms in patients.

Original language	English
Pages (from-to)	1925-1927
Number of pages	3
Journal	Archives of Internal Medicine
Volume	143
Issue number	10
DOIs	https://doi.org/10.1001/archinte.143.10.1925
State	Published - Nov 26 1983
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine

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abstract = "The postabsorptive urinary total (T), dialyzable (D), and nondialyzable (ND) hydroxyproline (HYPRO) tests were evaluated to determine whether the patterns of excretion varied according to the predominance of osteoblastic v osteolytic bone involvement in 58 patients with neoplastic disease. In patients with osteolytic lesions from multiple myeloma, elevated T and D levels with normal ND HYPRO values were observed, along with elevated D/ND ratios. In prostate cancer, the T, D, and ND values were all elevated and the D/ND ratio was normal. Patients with Hodgkin's disease had elevated T, D, and ND HYPRO levels, and the D/ND ratio was in the range of patients with prostate cancer. The data suggest that these collagen markers may be useful in the long-term evaluation of these neoplasms in patients.",

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AU - Maxwell, T. A.

AU - Hopkins, S. C.

AU - Soloway, M. S.

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