Total and nondialyzable hydroxyproline excretion in stage D2 prostate cancer

Stanley C. Hopkins; Genaro M. Palmieri; Harvey B. Niell; Mohammad Moinuddin; Mark S. Soloway

doi:10.1002/1097-0142(19840101)53:1<117::AID-CNCR2820530121>3.0.CO;2-0

Total and nondialyzable hydroxyproline excretion in stage D₂ prostate cancer

Stanley C. Hopkins, Genaro M. Palmieri, Harvey B. Niell, Mohammad Moinuddin, Mark S. Soloway

Urology

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

Hydroxyproline is excreted in urine as a breakdown product of normal bone turnover: A dialyzable (D) fraction (90% of total) reflects active bone destruction and a nondialyazble (ND) fraction reflects bone growth/regrowth. In metastatic prostate cancer where blastic osseous metastases predominate, disease progression on bone scan correlated with elevation of both total hydroxyproline excretion (7.84 + 1.28, P < 0.001) and the ND urinary level (0.94 ± 0.20, P < 0.01). In patients with a serially stable/improving scan, urinary excretion of each fraction (2.18 + 0.27 and 0.27 ± 0.01) was similar to that of men with no evidence of disease. For Stage D₂ prostate cancer, these two markers satisfactorily monitor osseous activity in the intervals between serial bone scintigraphy.

Original language	English (US)
Pages (from-to)	117-121
Number of pages	5
Journal	Cancer
Volume	53
Issue number	1
DOIs	https://doi.org/10.1002/1097-0142(19840101)53:1<117::AID-CNCR2820530121>3.0.CO;2-0
State	Published - Jan 1 1984

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19840101)53:1<117::AID-CNCR2820530121>3.0.CO;2-0

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Hopkins, S. C., Palmieri, G. M., Niell, H. B., Moinuddin, M., & Soloway, M. S. (1984). Total and nondialyzable hydroxyproline excretion in stage D₂ prostate cancer. Cancer, 53(1), 117-121. https://doi.org/10.1002/1097-0142(19840101)53:1<117::AID-CNCR2820530121>3.0.CO;2-0

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abstract = "Hydroxyproline is excreted in urine as a breakdown product of normal bone turnover: A dialyzable (D) fraction (90% of total) reflects active bone destruction and a nondialyazble (ND) fraction reflects bone growth/regrowth. In metastatic prostate cancer where blastic osseous metastases predominate, disease progression on bone scan correlated with elevation of both total hydroxyproline excretion (7.84 + 1.28, P < 0.001) and the ND urinary level (0.94 ± 0.20, P < 0.01). In patients with a serially stable/improving scan, urinary excretion of each fraction (2.18 + 0.27 and 0.27 ± 0.01) was similar to that of men with no evidence of disease. For Stage D2 prostate cancer, these two markers satisfactorily monitor osseous activity in the intervals between serial bone scintigraphy.",

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