Topographic thickness of Bowman's layer determined by ultra-high resolution spectral domain-optical coherence tomography

Aizhu Tao, Jianhua Wang, Qi Chen, Meixiao Shen, Fan Lu, Sander R. Dubovy, Mohamed Abou Shousha

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Purpose. To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian. Methods. Forty-four eyes of 22 healthy subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain-optical coherence tomography (SD-OCT) was used to assess the topographic thickness of the epithelium and the Bowman's layer across the cornea. Thicknesses at five locations, including the center, midperiphery, and periphery close to the limbus, on both the nasal and the temporal sides along the horizontal meridian, were analyzed. Results. Mean epithelial thickness at the central cornea was 52.5 ± 2.4 μm. It increased gradually from the center to the periphery (P < 0.001). There was no significant difference between the nasal side and the temporal side for epithelial thickness. The central Bowman's layer thickness was 17.7 ± 1.6 μm, and it remained constant from the center to the midperiphery (P > 0.05). However, thicknesses at the nasal and temporal periphery, 20.0 ± 1.9 μm and 19.8 ± 2.2 μm, respectively, were significantly greater than the central and midperipheral thicknesses (P < 0.001). Nasal and temporal thicknesses were similar on either side of the center. Conclusions. The epithelium and the Bowman's layer were not evenly distributed across the horizontal meridian of the cornea. SD-OCT provided useful information about topographic thickness of the different corneal layers in vivo.

Original languageEnglish (US)
Pages (from-to)3901-3907
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume52
Issue number6
DOIs
StatePublished - May 2011

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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