Topographic differences in the age-related changes in the retinal nerve fiber layer of normal eyes measured by stratus optical coherence tomography

William J Feuer, Donald L. Budenz, Douglas Anderson, Louis Cantor, David Greenfield, Jonathan Savell, Joel S. Schuman, Rohit Varma

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To determine whether there are regional differences in the age-related changes in peripapillary retinal nerve fiber layer (RNFL) thickness as measured by time-domain optical coherence tomography (OCT). METHODS: Fast peripapillary RNFL scans obtained with the Stratus time-domain OCT with nominal diameter of 3.46-mm centered on the optic disc were carried out on 425 normal participants over a wide age range. One eye was randomly selected for scanning or analysis. Average RNFL-, clock hour-, and quadrant-specific rates of RNFL thickness change were calculated and compared. RESULTS: The 425 study participants ranged in age from 18 to 85 years with mean (±SD) of 46 (±15) years. The mean (±SD) average measured RNFL thickness was 104.7 (±10.8) micrometers (μm). The decline in the average RNFL thickness was 2.4 μm per decade of age. Changes in RNFL thickness per decade of age ranged from -5.4 (P<0.001) at clock hour 1 to -0.9 (P=0.28) at clock hour 6. Similarly, the rate of thickness change per decade of age in the superior quadrant was -4.3 (P<0.001) versus -1.5 (P=0.006) in the inferior quadrant. The slopes of thinning superiorly and inferiorly were highly significantly different (P=0.001). CONCLUSIONS: The age-related decline in normal RNFL measurements does not occur at equal rates around the disc and occurs mainly superiorly.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalJournal of Glaucoma
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2011

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Optical Coherence Tomography
Nerve Fibers
Optic Disk

Keywords

  • age
  • optical coherence tomography
  • retinal nerve fiber layer

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Topographic differences in the age-related changes in the retinal nerve fiber layer of normal eyes measured by stratus optical coherence tomography. / Feuer, William J; Budenz, Donald L.; Anderson, Douglas; Cantor, Louis; Greenfield, David; Savell, Jonathan; Schuman, Joel S.; Varma, Rohit.

In: Journal of Glaucoma, Vol. 20, No. 3, 01.03.2011, p. 133-138.

Research output: Contribution to journalArticle

Feuer, William J ; Budenz, Donald L. ; Anderson, Douglas ; Cantor, Louis ; Greenfield, David ; Savell, Jonathan ; Schuman, Joel S. ; Varma, Rohit. / Topographic differences in the age-related changes in the retinal nerve fiber layer of normal eyes measured by stratus optical coherence tomography. In: Journal of Glaucoma. 2011 ; Vol. 20, No. 3. pp. 133-138.
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