Topically applied aspirin rapidly decreases histamine-induced itch

Gil Yosipovitch; John Ademola; Ping Lui; Smita Amin; Howard I. Maibach

Topically applied aspirin rapidly decreases histamine-induced itch

Gil Yosipovitch, John Ademola, Ping Lui, Smita Amin, Howard I. Maibach

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10^-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.

Original language	English (US)
Pages (from-to)	46-48
Number of pages	3
Journal	Acta dermato-venereologica
Volume	77
Issue number	1
State	Published - Feb 20 1997
Externally published	Yes

Keywords

thermal sensory analyzer
visual analogue scale

ASJC Scopus subject areas

Dermatology

Fingerprint Dive into the research topics of 'Topically applied aspirin rapidly decreases histamine-induced itch'. Together they form a unique fingerprint.

Cite this

@article{09bb5f2a53934a76ae3f5777b20e10e7,

title = "Topically applied aspirin rapidly decreases histamine-induced itch",

abstract = "The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.",

keywords = "thermal sensory analyzer, visual analogue scale",

author = "Gil Yosipovitch and John Ademola and Ping Lui and Smita Amin and Maibach, {Howard I.}",

year = "1997",

month = feb,

day = "20",

language = "English (US)",

volume = "77",

pages = "46--48",

journal = "Acta Dermato-Venereologica",

issn = "0001-5555",

publisher = "Society for the Publication of Acta Dermato-Venereologica",

number = "1",

}

TY - JOUR

T1 - Topically applied aspirin rapidly decreases histamine-induced itch

AU - Yosipovitch, Gil

AU - Ademola, John

AU - Lui, Ping

AU - Amin, Smita

AU - Maibach, Howard I.

PY - 1997/2/20

Y1 - 1997/2/20

N2 - The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.

AB - The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.

KW - thermal sensory analyzer

KW - visual analogue scale

UR - http://www.scopus.com/inward/record.url?scp=0031025053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031025053&partnerID=8YFLogxK

M3 - Article

C2 - 9059677

AN - SCOPUS:0031025053

VL - 77

SP - 46

EP - 48

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 1

ER -