Abstract
The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 46-48 |
| Number of pages | 3 |
| Journal | Acta Dermato-Venereologica |
| Volume | 77 |
| Issue number | 1 |
| State | Published - Feb 20 1997 |
| Externally published | Yes |
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Keywords
- thermal sensory analyzer
- visual analogue scale
ASJC Scopus subject areas
- Dermatology
Cite this
Topically applied aspirin rapidly decreases histamine-induced itch. / Yosipovitch, Gil; Ademola, John; Lui, Ping; Amin, Smita; Maibach, Howard I.
In: Acta Dermato-Venereologica, Vol. 77, No. 1, 20.02.1997, p. 46-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Topically applied aspirin rapidly decreases histamine-induced itch
AU - Yosipovitch, Gil
AU - Ademola, John
AU - Lui, Ping
AU - Amin, Smita
AU - Maibach, Howard I.
PY - 1997/2/20
Y1 - 1997/2/20
N2 - The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.
AB - The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.
KW - thermal sensory analyzer
KW - visual analogue scale
UR - http://www.scopus.com/inward/record.url?scp=0031025053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031025053&partnerID=8YFLogxK
M3 - Article
C2 - 9059677
AN - SCOPUS:0031025053
VL - 77
SP - 46
EP - 48
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 1
ER -