Topically applied aspirin rapidly decreases histamine-induced itch

Gil Yosipovitch; John Ademola; Ping Lui; Smita Amin; Howard I. Maibach

Topically applied aspirin rapidly decreases histamine-induced itch

Gil Yosipovitch, John Ademola, Ping Lui, Smita Amin, Howard I. Maibach

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10^-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.

Original language	English (US)
Pages (from-to)	46-48
Number of pages	3
Journal	Acta dermato-venereologica
Volume	77
Issue number	1
State	Published - 1997
Externally published	Yes

Keywords

thermal sensory analyzer
visual analogue scale

ASJC Scopus subject areas

Dermatology

Cite this

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AU - Ademola, John

AU - Lui, Ping

AU - Amin, Smita

AU - Maibach, Howard I.

PY - 1997

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AB - The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.

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Topically applied aspirin rapidly decreases histamine-induced itch

Abstract

Keywords

ASJC Scopus subject areas

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