Topically applied aspirin rapidly decreases histamine-induced itch

Gil Yosipovitch, John Ademola, Ping Lui, Smita Amin, Howard I. Maibach

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.

Original languageEnglish (US)
Pages (from-to)46-48
Number of pages3
JournalActa Dermato-Venereologica
Volume77
Issue number1
StatePublished - Feb 20 1997
Externally publishedYes

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Histamine
Aspirin
Pain Threshold
Hot Temperature
Visual Analog Scale
Injections
Methylene Chloride
Therapeutics

Keywords

  • thermal sensory analyzer
  • visual analogue scale

ASJC Scopus subject areas

  • Dermatology

Cite this

Yosipovitch, G., Ademola, J., Lui, P., Amin, S., & Maibach, H. I. (1997). Topically applied aspirin rapidly decreases histamine-induced itch. Acta Dermato-Venereologica, 77(1), 46-48.

Topically applied aspirin rapidly decreases histamine-induced itch. / Yosipovitch, Gil; Ademola, John; Lui, Ping; Amin, Smita; Maibach, Howard I.

In: Acta Dermato-Venereologica, Vol. 77, No. 1, 20.02.1997, p. 46-48.

Research output: Contribution to journalArticle

Yosipovitch, G, Ademola, J, Lui, P, Amin, S & Maibach, HI 1997, 'Topically applied aspirin rapidly decreases histamine-induced itch', Acta Dermato-Venereologica, vol. 77, no. 1, pp. 46-48.
Yosipovitch, Gil ; Ademola, John ; Lui, Ping ; Amin, Smita ; Maibach, Howard I. / Topically applied aspirin rapidly decreases histamine-induced itch. In: Acta Dermato-Venereologica. 1997 ; Vol. 77, No. 1. pp. 46-48.
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