Topically applied aspirin rapidly decreases histamine-induced itch

Gil Yosipovitch, John Ademola, Ping Lui, Smita Amin, Howard I. Maibach

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized thermal sensory analyzer (TSA). Following histamine injection aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10-8) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.

Original languageEnglish (US)
Pages (from-to)46-48
Number of pages3
JournalActa dermato-venereologica
Volume77
Issue number1
StatePublished - Feb 20 1997
Externally publishedYes

Keywords

  • thermal sensory analyzer
  • visual analogue scale

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Yosipovitch, G., Ademola, J., Lui, P., Amin, S., & Maibach, H. I. (1997). Topically applied aspirin rapidly decreases histamine-induced itch. Acta dermato-venereologica, 77(1), 46-48.