TY - JOUR
T1 - Topical oxygen emulsion
T2 - A novel wound therapy
AU - Davis, Stephen C.
AU - Cazzaniga, Alejandro L.
AU - Ricotti, Carlos
AU - Zalesky, Paul
AU - Hsu, Li Chien
AU - Creech, Jeffrey
AU - Eaglstein, William H.
AU - Mertz, Patricia M.
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Objective: To investigate the use of a topical oxygen emulsion (TOE), consisting of a supersaturated oxygen suspension using perfluorocarbon components, on second-degree burns and partial-thickness wounds. Design: Oxygen is a required substance for various aspects of wound repair, and increased oxygen tension in a wound has been shown to stimulate phagocytosis and to reduce the incidence of wound infection. Second-degree burns and partial-thickness wounds were created on the backs of specific pathogen-free pigs. Wounds were then randomly assigned to 1 of the following treatment groups: TOE, TOE vehicle, or air-exposed control. Main Outcome Measure: Wounds were assessed for complete epithelialization using a salt-split technique. Results: The TOE was able to significantly (P =.001) enhance the rate of epithelialization compared with both vehicle and untreated control. These data suggest that topical oxygen may be beneficial for acute and burn wounds. Conclusions: The results obtained from this double-blind, control, in vivo study demonstrate that TOE can significantly enhance the rate of epithelialization of partialthickness excisional wounds and second-degree burns. These findings could have considerable clinical implications for patients with surgical and burn wounds by providing functional skin at an earlier date to act as a barrier against environmental factors, such as bacteria invasion. Other types of wounds may also benefit from this therapy (eg, chronic wounds and surgical incisions). Additional studies, including clinical studies, are warranted.
AB - Objective: To investigate the use of a topical oxygen emulsion (TOE), consisting of a supersaturated oxygen suspension using perfluorocarbon components, on second-degree burns and partial-thickness wounds. Design: Oxygen is a required substance for various aspects of wound repair, and increased oxygen tension in a wound has been shown to stimulate phagocytosis and to reduce the incidence of wound infection. Second-degree burns and partial-thickness wounds were created on the backs of specific pathogen-free pigs. Wounds were then randomly assigned to 1 of the following treatment groups: TOE, TOE vehicle, or air-exposed control. Main Outcome Measure: Wounds were assessed for complete epithelialization using a salt-split technique. Results: The TOE was able to significantly (P =.001) enhance the rate of epithelialization compared with both vehicle and untreated control. These data suggest that topical oxygen may be beneficial for acute and burn wounds. Conclusions: The results obtained from this double-blind, control, in vivo study demonstrate that TOE can significantly enhance the rate of epithelialization of partialthickness excisional wounds and second-degree burns. These findings could have considerable clinical implications for patients with surgical and burn wounds by providing functional skin at an earlier date to act as a barrier against environmental factors, such as bacteria invasion. Other types of wounds may also benefit from this therapy (eg, chronic wounds and surgical incisions). Additional studies, including clinical studies, are warranted.
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U2 - 10.1001/archderm.143.10.1252
DO - 10.1001/archderm.143.10.1252
M3 - Article
C2 - 17938338
AN - SCOPUS:35348985381
VL - 143
SP - 1252
EP - 1256
JO - JAMA Dermatology
JF - JAMA Dermatology
SN - 2168-6068
IS - 10
ER -