Topical ciprofloxacin treatment of Pseudomonas keratitis in rabbits

Terrence O'Brien, M. R. Sawusch, J. D. Dick, J. D. Gottsch

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Abstract

Ciprofloxacin is a new quinolone antibiotic that is highly active in vitro against Pseudomonas aeruginosa. A rabbit model of bacterial keratitis was used to assess the in vivo efficacy of topical ciproflaxacin. Albino rabbits received intrastromal injections of 5 x 102 aminoglycoside-resistant P aeruginosa organisms. At five hours after inoculation, ciprofloxacin (3 mg/mL) therapy was initiated (one drop every 30 minutes for 12 hours). Corneal tissue was then excised for bacterial colony counts. No organisms were recovered from ciprofloxacin-treated eyes, compared with an averaged of 3.1 x 107 organisms per milliliter recovered from untreated controls. This model suggests that topical ciprofloxacin may be clinically useful in treatment of aminoglycoside-resistant P aeruginosa keratitis.

Original languageEnglish
Pages (from-to)1444-1446
Number of pages3
JournalArchives of Ophthalmology
Volume106
Issue number10
StatePublished - Jan 1 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

O'Brien, T., Sawusch, M. R., Dick, J. D., & Gottsch, J. D. (1988). Topical ciprofloxacin treatment of Pseudomonas keratitis in rabbits. Archives of Ophthalmology, 106(10), 1444-1446.