Topical application of the Wnt/β-catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia

Antonella Tosti, Martin N. Zaiac, Agnese Canazza, Fabian Sanchis-Gomar, Helios Pareja-Galeano, Rafael Alis, Alejandro Lucia, Enzo Emanuele

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Activation of the WNT/β-catenin pathway has emerged as a potential therapeutic target in androgenetic alopecia (AGA). Methyl vanillate (MV) - a safe plant-derived ingredient - has been recently shown to activate the WNT/β-catenin signaling. Objectives Two distinct substudies were conducted. First, we designed a 6-month, uncontrolled, open-label clinical study to investigate whether topically applied MV may increase hair count and hair mass index (HMI) in female AGA. Second, we conducted a molecular study on the effect of MV on WNT10B mRNA expression in scalp biopsies of women with AGA. Methods: A total of 20 Caucasian women (age range: 25-57 years) with AGA (Sinclair grade 1-2) were included. The research product was an alcohol-free formulation supplied in the form of a spray containing 0.2% MV as the active ingredient. Results: In the clinical study, hair count and HMI were found to increase at 6 months by 6% (P <0.01) and 12% (P <0.001), respectively, compared with baseline. No participant discontinued treatment due to adverse effects, and the overall patient satisfaction was good. At the molecular level, the topical application of the research product resulted in a 32% increase in WNT10B mRNA expression levels in the temporal scalp area (P <0.001). Conclusion: Our pilot data suggest that topical MV can increase hair count and HMI by inducing WNT10B expression in the scalp, potentially serving as a novel treatment strategy for female AGA.

Original languageEnglish (US)
JournalJournal of Cosmetic Dermatology
DOIs
StateAccepted/In press - 2016

Fingerprint

Catenins
Alopecia
Hair
Scalp
Messenger RNA
Patient Satisfaction
Research
Therapeutics
Alcohols
Biopsy

Keywords

  • Androgenetic alopecia
  • Female pattern hair loss
  • Hair count
  • Hair mass index
  • WNT/β-catenin
  • Women

ASJC Scopus subject areas

  • Dermatology

Cite this

Topical application of the Wnt/β-catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia. / Tosti, Antonella; Zaiac, Martin N.; Canazza, Agnese; Sanchis-Gomar, Fabian; Pareja-Galeano, Helios; Alis, Rafael; Lucia, Alejandro; Emanuele, Enzo.

In: Journal of Cosmetic Dermatology, 2016.

Research output: Contribution to journalArticle

Tosti, Antonella ; Zaiac, Martin N. ; Canazza, Agnese ; Sanchis-Gomar, Fabian ; Pareja-Galeano, Helios ; Alis, Rafael ; Lucia, Alejandro ; Emanuele, Enzo. / Topical application of the Wnt/β-catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia. In: Journal of Cosmetic Dermatology. 2016.
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abstract = "Background: Activation of the WNT/β-catenin pathway has emerged as a potential therapeutic target in androgenetic alopecia (AGA). Methyl vanillate (MV) - a safe plant-derived ingredient - has been recently shown to activate the WNT/β-catenin signaling. Objectives Two distinct substudies were conducted. First, we designed a 6-month, uncontrolled, open-label clinical study to investigate whether topically applied MV may increase hair count and hair mass index (HMI) in female AGA. Second, we conducted a molecular study on the effect of MV on WNT10B mRNA expression in scalp biopsies of women with AGA. Methods: A total of 20 Caucasian women (age range: 25-57 years) with AGA (Sinclair grade 1-2) were included. The research product was an alcohol-free formulation supplied in the form of a spray containing 0.2{\%} MV as the active ingredient. Results: In the clinical study, hair count and HMI were found to increase at 6 months by 6{\%} (P <0.01) and 12{\%} (P <0.001), respectively, compared with baseline. No participant discontinued treatment due to adverse effects, and the overall patient satisfaction was good. At the molecular level, the topical application of the research product resulted in a 32{\%} increase in WNT10B mRNA expression levels in the temporal scalp area (P <0.001). Conclusion: Our pilot data suggest that topical MV can increase hair count and HMI by inducing WNT10B expression in the scalp, potentially serving as a novel treatment strategy for female AGA.",
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AU - Tosti, Antonella

AU - Zaiac, Martin N.

AU - Canazza, Agnese

AU - Sanchis-Gomar, Fabian

AU - Pareja-Galeano, Helios

AU - Alis, Rafael

AU - Lucia, Alejandro

AU - Emanuele, Enzo

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