Topical and biologic therapies for diabetic foot ulcers

Achieving healing in diabetic foot ulcers (DFUs) can be difficult, and despite the implementation of standard of care measures, healing rates remain unsatisfactory. The best management strategy to achieve more successful outcomes and avoid amputations is to perform a systematic approach. This includes offloading of the affected foot, infection control, correction of arterial disease and good wound care. Here the different topical and biologic therapies used in the management of DFUs to achieve a balanced, healthy, and pro-healing state, prevent limb loss, and improve quality of life for patients are reviewed.