Tolerance and pancreatic islet transplantation

Luca A Inverardi, Camillo Ricordi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Islet transplantation holds renewed promise as a cure for type I diabetes mellitus. Results of recent clinical trials have shown remarkable success, and have reignited universal optimism for this procedure. In spite of this success, the need for life-long immunosuppression of the recipient still limits islet transplantation to patients with poorly controlled diabetes or to those requiring kidney transplantation. It is obvious that the achievement of immunological tolerance would broaden the indication for islet transplantation to a much larger cohort of patients with type I diabetes mellitus, most likely preventing long-term complications and contributing to a much improved quality of life. Increased understanding of the basic mechanisms of tolerance induction has resulted in the implementation of numerous experimental approaches to achieve long-term survival of islet grafts in the absence of chronic immunosuppression. In this brief review we will attempt to summarize the current status of research and knowledge.

Original languageEnglish
Pages (from-to)759-765
Number of pages7
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume356
Issue number1409
DOIs
StatePublished - May 29 2001

Fingerprint

Islets of Langerhans Transplantation
insulin-dependent diabetes mellitus
transplantation
immunosuppression
islets of Langerhans
Medical problems
diabetes
tolerance
Type 1 Diabetes Mellitus
kidney transplant
Immunosuppression
quality of life
clinical trials
Graft Survival
Grafts
Kidney Transplantation
Quality of Life
Clinical Trials
Research

Keywords

  • Immunological tolerance
  • Islet transplantation
  • Islets of Langerhans
  • Transplantation
  • Type I diabetes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Tolerance and pancreatic islet transplantation. / Inverardi, Luca A; Ricordi, Camillo.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 356, No. 1409, 29.05.2001, p. 759-765.

Research output: Contribution to journalArticle

@article{db39bacc71604be1b1f1411129cee40f,
title = "Tolerance and pancreatic islet transplantation",
abstract = "Islet transplantation holds renewed promise as a cure for type I diabetes mellitus. Results of recent clinical trials have shown remarkable success, and have reignited universal optimism for this procedure. In spite of this success, the need for life-long immunosuppression of the recipient still limits islet transplantation to patients with poorly controlled diabetes or to those requiring kidney transplantation. It is obvious that the achievement of immunological tolerance would broaden the indication for islet transplantation to a much larger cohort of patients with type I diabetes mellitus, most likely preventing long-term complications and contributing to a much improved quality of life. Increased understanding of the basic mechanisms of tolerance induction has resulted in the implementation of numerous experimental approaches to achieve long-term survival of islet grafts in the absence of chronic immunosuppression. In this brief review we will attempt to summarize the current status of research and knowledge.",
keywords = "Immunological tolerance, Islet transplantation, Islets of Langerhans, Transplantation, Type I diabetes",
author = "Inverardi, {Luca A} and Camillo Ricordi",
year = "2001",
month = "5",
day = "29",
doi = "10.1098/rstb.2001.0849",
language = "English",
volume = "356",
pages = "759--765",
journal = "Proceedings of the Royal Society B: Biological Sciences",
issn = "0800-4622",
publisher = "Royal Society of London",
number = "1409",

}

TY - JOUR

T1 - Tolerance and pancreatic islet transplantation

AU - Inverardi, Luca A

AU - Ricordi, Camillo

PY - 2001/5/29

Y1 - 2001/5/29

N2 - Islet transplantation holds renewed promise as a cure for type I diabetes mellitus. Results of recent clinical trials have shown remarkable success, and have reignited universal optimism for this procedure. In spite of this success, the need for life-long immunosuppression of the recipient still limits islet transplantation to patients with poorly controlled diabetes or to those requiring kidney transplantation. It is obvious that the achievement of immunological tolerance would broaden the indication for islet transplantation to a much larger cohort of patients with type I diabetes mellitus, most likely preventing long-term complications and contributing to a much improved quality of life. Increased understanding of the basic mechanisms of tolerance induction has resulted in the implementation of numerous experimental approaches to achieve long-term survival of islet grafts in the absence of chronic immunosuppression. In this brief review we will attempt to summarize the current status of research and knowledge.

AB - Islet transplantation holds renewed promise as a cure for type I diabetes mellitus. Results of recent clinical trials have shown remarkable success, and have reignited universal optimism for this procedure. In spite of this success, the need for life-long immunosuppression of the recipient still limits islet transplantation to patients with poorly controlled diabetes or to those requiring kidney transplantation. It is obvious that the achievement of immunological tolerance would broaden the indication for islet transplantation to a much larger cohort of patients with type I diabetes mellitus, most likely preventing long-term complications and contributing to a much improved quality of life. Increased understanding of the basic mechanisms of tolerance induction has resulted in the implementation of numerous experimental approaches to achieve long-term survival of islet grafts in the absence of chronic immunosuppression. In this brief review we will attempt to summarize the current status of research and knowledge.

KW - Immunological tolerance

KW - Islet transplantation

KW - Islets of Langerhans

KW - Transplantation

KW - Type I diabetes

UR - http://www.scopus.com/inward/record.url?scp=0035967489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035967489&partnerID=8YFLogxK

U2 - 10.1098/rstb.2001.0849

DO - 10.1098/rstb.2001.0849

M3 - Article

C2 - 11375078

AN - SCOPUS:0035967489

VL - 356

SP - 759

EP - 765

JO - Proceedings of the Royal Society B: Biological Sciences

JF - Proceedings of the Royal Society B: Biological Sciences

SN - 0800-4622

IS - 1409

ER -